Balanced Translocation 2:19

[anne0922]

I'm 38 years old and TTC since 04/06.  Had 3 miscarriages in a row. Has anyone had this type of translocation and had success?  I see Marie was successful with her balanced translocation and wondered if anyone else was...

[anne0922]

Thanks for all the posts ladies. Sorry this response is so late!  My translocation is
t(2;19) and they gave me odds of 50% m/c rate, but also possibly 75%.  I'm choosing the lessor of the two.  I'm currently 39 and had my 4th miscarriage in January, so I"m still trying.  Unfortunately, my age has come into play.  My 3rd m/c was tested and it had a balanced translocation, but it didn't m/c due to that.  It actually was due to a Trisomy 22, so I was upset about that.  It's a common occurence due to maternal age of the eggs.  So, that being said, I'm still holding out hope, but DH and I have decided to stop TTC when I turn 40.  With all the other 'normal' issues that can arrise with age and my BT, it is just a decision we needed to make for us.

But, I'm still holding out that I can get preggers one last time before Feb 2009, so keep me in your prayers!

AH

[rpmcqueen]

My sister has this type of translocation t(2;19) and has two healthy children.  She has had quite a few miscarriages, but is pregnant and hopeful with her third child.  Just keep at it - there are many cases of conceiving!  I am being tested for it now that I know my sister has it, but I also have two healthy children, so I hope this gives you some confidence going forward!

[Sheri1972]

Hello!

It's when a bit of one chromosome recombines with another chromosome.  A balanced translocation is when there is a "swap" of genetic information, so none is lost or gained.  I'm assuming, Anne, that your balanced translocation is between chromosome 6 and 14?  Is it a Robertsonian translocation?

Balanced translocations usually don't effect the carrier, but in carriers trying to have a child, it does increase their risk of producing an egg or sperm with unbalanced translocations, which often leads to miscarriages.    

If you have miscarried several times, and there seems to be no hormonal reason for it (progesterone, etc), I would definitely go see a genetic counselor to have a karyotype done to make sure everything is okay with both you and your partner.

Sheri
(I'm a geneticist...)

[adgal]

May I ask what a translocation is?  I have just m/c 3 times in a row, and have not heard this term.  Is it something my OB should be testing for?  Thanks for the info, I appreciate it.

[jenzoe]

I have a little boy who was born on my second pregnancy.  I am now pregnant for the fifth time (yikes) and not too hopeful that this one will make it.   Supposedly, I have a 50% chance of miscarriage every time because of my 6:14 translocation.  Have you had your odds done?