pregnancy

[junebug1818]

I have a patient who has now incurred her third miscarriage -all between 7-8 1/2 weeks. I ran karyotypes on her and her spouse.. She appears to have a reciprocal balanced translocation with a piece of chomosome 4 attached to a piece of chromosome 15.. I have to believe this is the cause of her losses.. ie unbalanced translocations in the fetuses..The last fetus was not able to be assessed because of cytolysis.
Is there any percentage I can give her regarding future miscarriages... At this point she is 3 for 3..I would like to believe it should be 50% and she should keep trying if she can handle it...
Thank you
June

[lozzaj83]

Hi

I have a reciprical balanced translocation of 17 and 21.
I was told that I have about a 50% chance of convieving naturally by my genetics councellor. The best way mu husband describes it is:

If you put all the ingredients in a bowl to make a cake - if all equal amount go in, in the right order a baby will come out. However If you don't put sugar in, but put 2 lots of flour the cake won't rise!

I have had 4 MC now. all within about 2 years. I have been offered the Genetic IVF route which identify's the eggs with the translocation and matches with healthy eggs. However here in the UK - you have to use protection whilst they apply for a licence and funding. Otherwise if you fall pregnant naturally its a big waste of money. So thats the catch 22. You miss out on 2 years of trying to concieve a baby nautrally while the funding comes through or you try the IVF route which could only give you a 30% chance of sucess.

These guys are very good: http://www.rarechromo.org/html/home.asp

Hope this helps. Tell her not to give up hope. I haven't! IT WILL HAPPEN ONE DAY!!!!

[ku111]

I am just a nurse but we do a lot of high risk and I thought IVF/PGD was the most likely route to go.  Don't you wish everyone could just have a normal pregnancy, especially the ones that really want a baby?  Breaks my heart but miracles happen every day.  Goodluck with them!

[diamondintherough79]

I cant answer your question medically but, a friend of mine has had a chromosonal problem with her pregnancies and miscarried 9x, she is now 7.5 months pregnant with a healthy baby. She didnt have any treatments and conceived naturally.