Are these thyroid problems?

[sheker]

I'm hypothyroid patient. For last 8 months I have several issues going on with my health.
Started with Rashes and Itchy on groin area then inflammation of eyes, legs, foot and loose stools.Also muscle pain and painful itchy. Also tingling,needles, pins on the legs and foot.
I am seeing several doctor's but no help.

Currently Angiotensin-1 converting enzyme  (81) and B12(1266) are high . I took B12 vitamins for last couple of months, probably that's the cause for B12 increase and not sure about enzyme level elevation.

Brain MRI and EEG results are normal.Skin biopsy is normal, EMG test is normal.
Not sure what else causing?

Not sure hypothyroid is causing for all these issues.

Any advice is great and appreciated.

[Red_Star]

Mayo Clinic - Angiotensin Converting Enzyme, Serum..

"Currently, it appears that ACE activity reflects the severity of sarcoidosis: 68% positivity in those with stage I sarcoidosis, 86% in stage II sarcoidosis, and 91% in stage III sarcoidosis. Serum ACE also appears to reflect the activity of the disease; there is a dramatic decrease in enzyme activity in some patients receiving prednisone.

Other conditions such as Gaucher disease, leprosy, untreated hyperthyroidism, psoriasis, premature infants with respiratory distress syndrome, adults with amyloidosis, and histoplasmosis have been associated with increased levels of ACE."

[sheker]

Thanks for your reply. I haven't visit doctor yet after enzyme increase, doctor's office mentioned they don't have serious concerns at this time but asked me to come for followup on 08/10.I will update you.

[Barb135]

I hope you don't mind, but I have a lot of questions to ask; once I have those answers, I might be able to help you.

Do you have thyroid related test results you can post so we can see what your actual thyroid hormone levels are?  You should have Free T4, Free T3 and TSH tested.

Are you taking a replacement thyroid hormone medication?  If so, what medication, dosage and how long have you been taking it?  

Have you had antibody tests to determine if you have Hashimoto's Thyroiditis?  

Do you know what your vitamin B-12 level was prior to taking the supplement? Your level isn't that high and B-12 isn't toxic, so that's not going to hurt you.

Has anyone suggested sarcoidosis as a possible diagnosis for the rash, eye and other problems, since you have the elevated angiotensin converting enzymes?

[sheker]

Thanks Barb for your reply.
I am taking Levothyroxin 75mcg.
Antibodies tested 7 yrs ago.

Previous Results (09/25/2016 ), before taking B12 Vitamin and D Vitamins:
D Vitamin (25-OH) : 18
B12 : 228


Recent Test 07/05/2017:
Kreatine Kinase : 199
ANGIOTENSIN-1-CONVERTING ENZYME: 81
B12 :1266
D, Vitamin= 43
TSH : 3.62
T4, Free=1.4

I didn't see neurologist yet, he's waiting for all test results , one more test congnitive is pending, he gave appointment for 08/10. Probabaly he'll investigate for sarcoidosis.