Hypo - feeling better and then back to old state

[sharanbr]

I have had this experience 3-4 times. Everytime I start a thyroid supplement, I feel better for a few days before symptoms return. This has happened when I started Thyronorm and then again everytime dosage was increased. I felt better for a week or so and symptoms return back.

I am just thinking whether body is taking time and then starts opposing conversion of t4 to t3.

[sharanbr]

Gimel,

What you are referring to a classical issue in any feedback systems.. But that is an Transient effect until body finds the right level.

Also,  I am not saying everyone resists to higher t4. Probably,  only few.

[gimel]

Not exactly sure what you are asking.  Serum thyroid hormone levels are the sum of endogenous sources (natural thyroid hormone produced by the gland) and exogenous sources (thyroid medication).  When starting on thyroid meds, the TSH level drops and the output of natural thyroid hormone is diminished.  So, there will be very little increase in total serum thyroid hormone levels until the TSH is basically suppressed and serum levels are totally the result of thyroid meds.  There are scientific studies that show this effect in the case of central as well as primary hypothyroidism.

If the body really resisted higher T4 by creating anti T3 hormones, then how could anyone ever become hyperthyroid?

[sharanbr]

Dear gimel,

Lower TSH is in response to increased T3 levels & indirectly T4 (in my understanding). So, that should not matter, don't you think?

I am wondering if body starts resisting higher T4 by creating more anti T3 harmones?

[gimel]

Have you monitored your test results from before and after a med change.  Sometimes the med increase causes the TSH to drop and thus less production of natural thyroid hormone, which is both T4 and T3,  Since the Thyronorm is only T4, I guess that you could speculate that the med change is affecting the level of Free T3 unless conversion is adequate to make up for the loss in natural T3 production.  

All this is part of the rationale for gradually increasing thyroid meds as necessary to relieve symptoms.