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High TSH and Thyroid Peroxidase Antibodies, but normal T3 and T4

I'm a little confused about my test results, and I'm hoping that I can get some insight from the community.
Here are my results

TSH is 5.76
FT3 is 3.0
FT4 is 1.1
Thyroblobulin Auto Antibody is 27.9
Thyroid Peroxidase Auto Antibody is 453
Thyroid is enlarged, but I hadn't noticed until my Dr. discovered this (and sent me for an ultrasound to confirm).

What does this mean?  Since my T3 and T4 are in normal range, putting me on replacement therapy wouldn't really do anything would it?
Also, my blood test revealed a vitamin D deficiency.  If was 17.
Best Answer
Avatar universal
You really do need to supplement your Vitamin D level to get it up over the middle of its range.  

Beyond that, a test result like yours, for TPO ab, almost always means Hashimoto's Thyroiditis, which is the most common cause for diagnosed hypothyroidism.  If I assume that the ranges for your Free T3 and Free T4 are similar to those seen so often, then your Free T3 and Free T4 are within the so-called "normal' range, but your Free T3 is in the lower half of its range, which frequently is accompanied by hypothyroid symptoms.   The range is too broad to really be a functional range, due to the erroneous way it was established.  Your Free T4 would be considered as adequate.  

So first, please post the reference ranges for the Free T3 and Free T4, as shown on the lab report.  Second, please tell us about any symptoms you are having.  Third, I suggest that when you go for testing again, you should also request to be tested for Vitamin B12, and ferritin.  Even though men are usually assumed to have adequate iron levels, ferritin is so important for someone that is treated for hypothyroidism, you need to make sure your level is adequate.

  



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Avatar universal
I agree with goolarra.  Your labs and symptoms are those of Hashimoto's Thyroiditis, which is not going to disappear as the doctor would like.  

I felt the need to point out that being and Endo does not guarantee a good thyroid doctor.  Many specialize in diabetes, not thyroid.  Also, many have the "Immaculate TSH Belief" and only pay attention to TSH test results, which does not work for the patient.  Others that go beyond TSH usually use "Reference Range Endocrinology" and will tell you that a thyroid test that falls anywhere within the range is adequate.  That is very wrong.  

A good thyroid doctor will treat a hypo patient clinically by testing and adjusting Free T4 and Free T3 as needed to relieve hypo symptoms.  Symptom relief should be all important, not just test results.  

I would not want to wait for 6 weeks only to find out that the Endo is not a good thyroid doctor.  If you will tell us your location, perhaps we can suggest a doctor that has been recommended by thyroid patients.
Helpful - 0
Avatar universal
That's what I was thinking.  The Dr. is saying he doesn't want to put me on medication because it is a lifelong medication, and he thinks my thyroid problem will eventually correct itself.  

I don't have much faith in Drs. though, since earlier this year I had to endure one medical mistake after another while hospitalized. Came close to losing my life because of numerous mistakes.  

This is my 2nd Endocrinologist, the first one was worse.  I have an appt. with a new one, but he is booked for another 6 weeks. Hopefully he is worth the wait! In the meantime, I take lots of vitamins now, hoping something will give me some energy. Not sure what else to do
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Avatar universal
Your current labs are clearly hypo with both FT3 and FT4 on the floor of the range and TSH elevated.  

Your TPOab indicates you have Hashimoto's thyroiditis.  It's not unusual in early stages of Hashi's to swing from hypo to hyper, but you will settle into total hypo at some point.

With your TPOab, I don't know why they haven't diagnosed Hashi's and are thinking any kind of temporary thyroiditis.  You should be on meds.
Helpful - 0
Avatar universal
I have been going back and forth with Drs. for almost 3 months due to abnormal Thyroid tests. I was leaning toward Hyperthyroid, but my last test showed possibly Hypothyroid.
My Drs. are saying they think I have temporary Thyroiditis, and they do not want to give me Thyroid medication until they are sure it is not going to correct itself.
They believe the cause is the Contrast used from the 12 CT scans I had earlier this year due to a botched Gall Bladder surgery. I ended up with Sepsis and hospitalized for 6 weeks.

My most recent results:
TSH 19.6 (.40-4.50)
Free T3 2.3 (2.3-4.2)
Free T4 .8 (.8-1.8)
Thyroid Peroxidase Antibodies 661 (.0-8.9)

I feel like I've been run over by a truck most of the time and am growing tired of waiting this out. Main Symptoms include: lost about 1/2 my hair, extreme fatigue, overall achy, brain fog/forgetful, higher than normal blood pressure.
Helpful - 0
Avatar universal
That feeling is usually associated with the adrenal function.  If you get your levels optimized and start feeling good again and still notice the same thing then you could try to get a diurnal saliva cortisol panel of 4 tests taken at different times during the day, and see where your results fell compared to the range. .  
Helpful - 0
Avatar universal
What would cause no longer having the flight or fight syndrome when being in situations that should trigger it. I use to experience it when placed in those positions. I haven't experienced any of those feelings in over 2 years. I asked endo Dr and I was brushed off.
Helpful - 0
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