I'm a 21 year old female college student, and since I hit puberty when I around 12 years old, I have had trouble losing weight... I'm about 6 foot 1, 250 lbs but I'm very active and I workout 5 days a week, resistance training for an hour and sometimes cardio. I play basketball once a week as well. I found out 5 years ago that I had an enlarged thyroid, which I blame for the massive weight gain and extreme hair loss. However, after going to the doctor numerous times, all my tests came out "normal". I know something's wrong... I still have hair loss, I can't lose any weight, I'm always fatigued, and I get this weird burning, achy sensation in my throat every once and a while. Sometimes I have heavy periods, have random nausea, and my voice is deep. Nevertheless, I really need to lose weight; I have almost every genetic factor leading to CVD, diabetes, HBP, etc in my family history. Weight loss and energy is essential! Please help! What can I do? What could it be?