As a general psychiatrist I test a lot of people for thyroid disorders. I usually test TSH & Free T4 (FT4), since I frequently see clinically relevant hypothyroid sx (that also happen to be sx of depression) in people with TSH >3. In those people, I like to see the FT4.
I recently had a 35 yo, white female, not on hormones of any sort, including OCP. She complained of breast milk after taking 25mg of Seroquel, which has almost no proclivity to do that. 2 weeks after stopping the Seroquel, there was no change in the galactorrhea. She also said she was hypoglycemic & had a remote hx of significant head injury. Her labs were as follows:
TSH- 0.336 (0.4- 4)
FT4- 1.15 (0.8-1.9)
FT3- 2.3 (2.4-4.2)
Prolactin 112 (1.9-25)
Fasting Insulin 4 (3-19)
T.Chol 202, LDL 104, VLDL 12 & HDL 86
She was in the leuteal phase of her cycle, according to the LH, FSH & estradiole E2.
I am really curious about what appears to be conflicting thyroid tests, but threw in the others since I know everything affects everything in this wonderful creation of the human body. I am planning on testing the reverse T3 (rT3), but I saw a negative article from one of you on the usefulness of that test. I thought the rT3 could inhibit the conversion of T4- T3 & still provide negative feed back to the pituitary, thereby causing a low TSH. Is that accurate? I will obviously refer to an endocrinologist, but should I do the rT3 or maybe an TRH? I recognize that the anterior pituitary affects both the TSH & the prolactin. Maybe we should scan her brain before sending to endo? Any guidance will be greatly appreciated.
George Moses, D.O.