Believe me, you don't want me commenting before my morning coffee! LOL Us west coast kids work at a disadvantage...
All labs are from approximately the same time of day without meds prior to the draw?
Interesting...your FT4 results make me kind of curious about the direct range. It almost seems like the only difference IS the range. I'm kind of wondering if, in the lower ends of the direct and indirect ranges, the results aren't directly comparable, rather than only comparable as a percentage of range???
Neither FT3 nor FT4 has moved much. However, your FT3 is certainly very respectable at 79% of range. At the same time, it DOES have some room to move up. I'm glad to hear your symptoms are improving.
Cytomel does come in 25 mcg tablets...at least that would only be one split.
Have you considered switching to Tirosint...same meds a any other levo, but the only filler is water (gelcap)?
Really curious about your RT3 now...
Sorry, the range for the July Free T4 non-Direct is ( .8 - 1.8 ) it's curious that by that method, the T4 was right in the middle, higher than it measures by the Direct method. Makes sense I guess, since the estrogen I take can bind the hormone. The Direct method allows for that.
HA HA, no excuse, I'm in California, back to the salt mines ! Thanks so much for getting back to me. Hope you're feeling well.
Yeah, confusing isn't it ? So mad about the lab, they directly lied to me, never told me the rT3 wouldn't be processed with the other tests. Yes, all labs are without food and at 7-8 am. The only variable might be the time in my cycle of BHRT, as I take estrogen alone for days 1-10 and then add progesterone for days 11-25, then nothing for 5 days.
I'm w-a-a-y too ignorant to know what you mean about comparing the direct and indirect ranges. I CAN tell you that when I first started complaining about my thyroid, they said there was nothing wrong with it because my TSH back in 2004 was .78, then in 2005 it was 1.55 and I had bad symptoms...ALL of them except constipation, including practically hemorrhaging for the first 2 or 3 days of my period. I rapidly gained 40 lbs., though I don't eat a lot. My WBC was low, monocytes high, TIBC very high though ferritin was fine, and cholesterol rising alarmingly. I was bruising a lot, and the blood doctor said I had enlarged red blood cells indicating pernicious anemia. Absolute lymphocytes, whatever that is, were also low.
By 2007, when my voice was so hoarse I could barely speak, I was so pale I looked like a fat ghost, and even my eyebrows and pubic hair had gone missing, it was still "impossible" for me to be hypothryoid because my TSH was now 1.56 out of .49 - 5.50 (steadily going up for ME, but IN RANGE) and my Free T4 index (finally, the test) was 2.4 out of 1.4 - 3.8 and the Free T4 was 1.1 out of .8 - 1.8 The endo also did a T3 uptake test, which was 27 (22 - 35) SO I was fine and probably mentally ill. I was seriously depressed and was having non-stop panic attacks (which stopped when I finally got T3 in 2009) My serum ferritin level was 22 out of 10-291. At this point, she finally deigned to feel my throat, and an ultrasound revealed a multi-nodular thyroid and I was given a small amount of Synthroid, but "only to stop the growth of the nodules". The Synthroid on its own did nothing for the symptoms. I was putting cream on my skin 8 times a day.
So all of this certainly suggests to ME that there has to be some kind of resistance problem....which they say is rare and that I "can't have". Well. SOMEBODY has to have it, right ? all along I've said to them, "Yes, I understand that's normal for MOST people, but what if it's not normal for me?" I mean, my TSH more than DOUBLED, even if it was still in range. Now, on meds, my TSH is undetectable but I still have lingering symptoms such as non-pitting edema. That went away when I first went on T4-T3, but returned when the endos started screwing with my T3 meds because of the low TSH and is now stubbornly persistent. sigh.
My insurance doesn't cover Tirosint, but I have to do an appeal for the price of Cytomel anyway because I had a problem with the generic. They charge me by the pill rather than by my monthly dose. It's expensive. I agree it would be better to go back to splitting the 25.
Anyway, I too am hoping for some information from the rT3 test. In the meantime, My cholesterol has gone from a high of 220 back down to its usual 163 without changing anything but thyroid meds. It's been a long struggle.
If you want me to post other T4 tests I will....i've sure had enough of them. It seems to me the T4 needs to go up a little more, doesn't it ?
All the Best.
Thanks, I am feeling well. Can't play the west coast card with you, huh? I'm an east coast kid, so I always feel a little "off" in this time zone!
Are you taking B-12 shots for the PA?
Exactly, resistance problems are relatively rare, but, you're right, some people DO have them! However, untreated resistance symdromes are usually characterized by HIGH TSH levels along with HIGH FT3 and FT4 levels. The pituitary is trying to get even more hormone out of the thyroid even though levels are already high.
I'd have to do some research on the FT4 Direct range. My gut feeling is that "midrange" does not apply to it like it does to indirect. Midrange for indirect FT4, on the usual 0.8-1.8 range is 1.3. We tend to lop off the lower end of the range because the original "normal" population included a lot of people who were synpotomatic, but undiagnosed, and asymptomatic Hashi's. I looked at it a little yesterday, but didn't have time to get into it as much as I'd have liked. So, until I do that, I really don't know how to answer your question about whether your FT4 needs to go up or not. I'm wondering if the two ranges, in the 0.8-1.8 range are not relatively equivalent, but the direct method's upper limit floats a bit higher only because the direct method detects more.
Re; pernicious anemia: The blood doctor told me to use NOW brand sublingual complete B12, a dropper full per day, and I've done that ever since....years now. It has the other Bs as well. She said the key was to source B12 from methylcobalamin as the most easily absorbed. It stopped the bruising almost immediately.
Huh about the resistance. I thought I read that tissue resistance was characterized by low TSH and low Free T4, which I had, but I've read so much that it's hard to remember where I read it without searching through my copious bookmarks. I'll wait on the rT3 and proceed from there. I think I'm feeling just slightly speedy, but the persistent edema is confusing since my sodium and potassium are fine. It's kinda painful :- ( My instict is to raise the T4 and slightly lower the T3. dunno. My doc's no help. she's pissed that I can't find a decent endo. I'm not willing to get beaten up by them again.
Will post again after I get the labs back. Muchas gracias.