Hello, I had a thyroidectomy for Grave's Disease in 1993, and have been on a Levoxyl dose of 125 for awhile. For the last several months I've been fatigued/depressed, so I just started taking bupropion 10 days ago, the first 3 days at 150, then 300. I went in three days ago to Urgent Care because the previous night I couldn't sleep, felt itchy (no rash) all night, and I kept getting alarmingly intense muscle twitches all over. The itchiness was isolated, but a few weeks before, and since, I've had muscle twitches to varying degrees, mostly in my legs, but I get them in my hands, arms, back, sides, and at my temples as well. The doctor I saw recommended I go back down to 150 on the bupropion, which I have, and tested my thyroid and calcium levels. The calcium was 9.9, T3 was 2.6, "free thyroxin" (T4?) was 2.1, prolactin was 1.8, and my TSH was 0.03. From what I gather, all but the TSH levels were "ok", and the TSH level suggests too much thyroxin. Any thoughts on what I should make of all this? I'd appreciate any feedback.