how long for methimazole to work?

[firefly7]

How long did it take you guys for it to kick in?   Almost three weeks ago here were my labs:
TSH                  [L]  <0.01 uIU/mL              [0.30-4.70]
Free T4                   1.89 ng/dL                  [0.75-2.00]
FT3                  [H]  5.5 pg/mL                   [2.3-4.2]  

I'm on 10mg of methimazole which I take as 5mg twice a day.   I had a slow start with it two weeks ago, taking only 5mg as I am notorious for my medication reactions but as I'm okay so far I'm gone up to 10mg for the last three days.   Still the minute my beta block leaves my system my resting heartrate zooms up to 100 or with caffeine even more.   I'm cutting out the caffeine altogether now - bums me out because chocolate is my comfort food.   My first visit with the endo isn't for a couple weeks yet.    Thanks in advance!

[jazzin]

pretty positive it is the methimazole that is causing me to feel my nerves. Yesterday and today I purposely didn't take a pill to see how I would feel and I was felt fine. Definitely not taking anymore now until I hear from doctors office.

[jazzin]

I think what may have happened is I may have had a reaction to the methimazole. I've been on it since September of last year though and have felt fine taking it. Even felt as good as I've ever felt in December. I can remember 2 times other than recently where I had like anxiety while on it. Once when I first started taking it and once in the beginning of this year. Other than that I had been fine until recently.

[goolarra]

Have you asked your doctor about splitting the dose?  I don't know if that would help, but it sounds like you feel pretty well in the morning after taking your meds and then start feeling not so good in the afternoon as the meds wear off a little.  As I said, I don't know if that will help with methimazole, but it might be something to ask your doctor.  Best of luck with the adjustment.  Let me know how it goes.

[jazzin]

Talked to my doc (his nurse) today. She said he wanted me to go do blood work again so I went do that this morning and she told me that based upon the results of the blood work he was going to make an adjustment to my meds. It's wierd cause I'll feel fine in the mornings and after lunch is when I start feeling my nerves and I sometimes feel cold although it has been warming up to the 70's during the day. Hope this works.

[goolarra]

It still seems to me that 5 mg is too little for you and 10 is too much.  Why not ask your doctor if you can take 7.5 per day (perhaps by alternating 5/10)?  

[jazzin]

Past couple days I have started to feel jittery again. I'm pretty much at a loss for what to do. It comes and gos. Doesn't stay like this all day but have it as I'm typing this. It feels like my nerves but can't quite explain it. My endo reduced my dosage to 5 mgs two weeks ago. This is quite annoying and taxing on me.