Hello does anyone know if high estrogen has a connection with erythema nodosm? I been having erythema nodosm for about 8 months and can’t seem to find the cause of it. All my labs have came back normal but I haven’t checked my testosterone or estrogen levels. About 1 year ago before all this started I was having Inflammatory acne and cysts develop in my breasts, confirmed by ultrasound. Before I get my period I tend to be very depressed,moody, and randomly happy. I know that within the past 2 years my body has gone through these changes. I don’t have many nodules but when I get them they are in my legs and very painfull. The skin feels like if someone hit me with a bat. Please any feed back would help if trying my best to survive this :(