I’ve been taking Bactrim (sulfamethoxazole-tmp DS) for about 5 days due to an infected mosquito bite. I know with sulfa- antibiotics you cannot drink alcohol because it is thought the drug inhibits the alcohol dehydrogenase enzyme causing acetaldehyde build-up. This causes what is referred to as the disulfiram reaction consisting of flushing, nausea, vomiting, light headedness and rapid heart rate (very unpleasant). I took care not to have a sip of alcohol, I did however have a N-acutely tyrosine supplement (includes B6), a b-complex vitamin (also had b6, folate, no potassium though), a magnesium supplement and 5mg of adderall (prescribed daily and earlier in the morning) and a bromelian supplement. Within about 30-45 min of taking the supplements a started to feel nauseous, had to leave an even immediacy and vomited repeatedly, also had very shortness of breath and almost fainted. Eventually after puking for about 45 min I suddenly felt completely fine as if nothing had happened. My suspicion is the N-acetyl Tyrosine supplant reacted with the sulfamethoxazole but I haven’t been able to find any rationale to explain this. I am so curious how I had this reaction with no alcohol but some result of my supplements I believe. Anyone have any thoughts?!