Aa
VITAMIN-E AND RESVERATROL REPLICATE HCV
hello to all and hope my post finds u all in better health and spirit .
I am 38 years old and got infected with hcv 3 years ago , i went through the regular tx and relapsed within 2 weeks of completeing ( geno 1a ), anyway i now await the new treatments that are suppose to come out in the next year or two and will decide then as to what needs to be done .
(i did post once before about the same topic .. but got no feedback except from a genteleman named bill - thanks bill .)
the only reason i post is to share my story and make others aware of the harm of "vit e and resveratrol" .
well here we go again ....
last year in december all m liver enzimes were normal ie: ast 30 alt 30 , but i was still hcv + with a viral load of 9000 .
in feburary this year i started feeling a bit weak and decided that juiceing may be a good idea , i started juicing with strawberries , black and green grapes , carrots , pomegranade , and some lemon .
i was also having my regular supplements that include - milk thistle , vit b / c / and a multi vit withought iron .
after a few days of juicing and feeeling mentally good i added vitamin e to my supplement list - reading that it was a great anti-oxidant .
well i was due for a lft in march and my report came back with ast= 62 and alt 161 . i continued with the juice and the vit e not realinzing that they could be the culprit .
after 2 weeks of checking again my ast was 106 and alt 320 ... and thereafter another week they went up to ast- 116 and alt = 400 , i paniced and though what is it... what is it ..... here im trying to do everything thats good for my body and liver but whats going on .... then thanx to the mystic law of the universe i tumbeled upon this study .
Quote from the article.
"To date, only a limited number of studies have reported finding an influence of ordinary nutrients on hepatitis C virus (HCV) RNA replication. However, the effects of other nutrients on HCV RNA replication remain largely unknown.
Here, using this OR6 assay system, we comprehensively examined 46 nutrients from four nutrient groups: vitamins, amino acids, fatty acids, and salts. We found that three nutrients-beta-carotene, vitamin D(2), and linoleic acid-inhibited HCV RNA replication and that their combination caused additive and/or synergistic effects on HCV RNA replication. In addition, combined treatment with each of the three nutrients and interferon alpha or beta or fluvastatin inhibited HCV RNA replication in an additive manner, while combined treatment with cyclosporine synergistically inhibited HCV RNA replication. In contrast, we found that vitamin E enhanced HCV RNA replication and negated the effects of the three anti-HCV nutrients and cyclosporine but not those of interferon or fluvastatin. These results will provide useful information for the treatment of chronic hepatitis C patients who also take anti-HCV nutrients as an adjunctive therapy in combination with interferon. In conclusion, among the ordinary nutrients tested, beta-carotene, vitamin D(2), and linoleic acid possessed anti-HCV activity in a cell culture system, and these nutrients are therefore considered to be potential candidates for enhancing the effects of interferon therapy.".
link for the above study - http://aac.asm.org/cgi/content/short/51/6/2016
also then i did a little more reading and found this ...
AIM: To elucidate the effect of antioxidants, resveratrol (RVT) and astaxanthin (AXN), on hepatitis C virus (HCV) replication. METHODS: We investigated the effect of recent popular antioxidant supplements on replication of the HCV replicon system OR6. RVT is a strong antioxidant and a kind of polyphenol that inhibits replication of various viruses. AXN is also a strong antioxidant. The replication of HCV RNA was assessed by the luciferase reporter assay. An additive effect of antioxidants on antiviral effects of interferon (IFN) and ribavirin (RBV) was investigated. RESULTS: This is the first report to investigate the effect of RVT and AXN on HCV replication. In contrast to other reported viruses, RVT significantly enhanced HCV RNA replication. Vitamin E also enhanced HCV RNA replication as reported previously, although AXN did not affect replication. IFN and RBV significantly reduced HCV RNA replication, but these effects were dose-dependently hampered and attenuated by the addition of RVT. AXN did not affect antiviral effects of IFN or RBV. CONCLUSION: These results suggested that RVT is not suitable as an antioxidant therapy for chronic hepatitis.
heres the link for the above study - http://www.myhealthfulworld.com/content/an-antioxidant-resveratrol-significantly-enhanced-replication-hepatitis-c-virus
i since have completely stopped taking the vit e and the juice . please note that grapes , peanuts , strawberries and pomegranade all contain high amounts of resvetrol .
I also stopped taking the multivitamin withough iron as it contained vit e ...
i have discussed this topic with a few friends but they dont seem to think resvetrol and vit e can do any harm !!! i wonder !!
but the same hcv community will come down ure throat if u say u had a beer or a steak .... ( i dont drink or eat red meat anymore ) saying that alcohol replicates hcv ... and iron is bad .. u shouldnt even eat spinich ....
well i would also like to add that 2 weeks of no juice and vit e .... and milk thistle 2 times a day have bought my ast from 116 to 96 , and alt from 400 to 275 .
PLEASE MY FRIENDS be carefull of what u eat and drink when suffering from hcv ... saying that " its natural " dosent mean its good for us ... we have a specific disease .... mud is natural too - would we eat it !!!
people without liver disease can eat and drink all that they want ..including mud -;) ..... but not us ,
i may be wrong and do welcome ure inputs .
also before i leave - i need to ask u all a small question .
as i said earlier - i was infected ( not diagnosed ) with hcv 3 years ago , do i need to get a live biopsy done !!! i dont drink or eat red meat and oily food , my ultra sound shows no enlargement ... but i am tired and have fatgue all the time .... yes my liver enzimes are high .. but im pretty sure that the reason behind that is the resveratrol and the vit e tablets which i have stopped taking now . .
thanking u and wishing u all well - await ure inputs regarding the bx .. and hope u all find the above studies helpfull.
pacman
I am 38 years old and got infected with hcv 3 years ago , i went through the regular tx and relapsed within 2 weeks of completeing ( geno 1a ), anyway i now await the new treatments that are suppose to come out in the next year or two and will decide then as to what needs to be done .
(i did post once before about the same topic .. but got no feedback except from a genteleman named bill - thanks bill .)
the only reason i post is to share my story and make others aware of the harm of "vit e and resveratrol" .
well here we go again ....
last year in december all m liver enzimes were normal ie: ast 30 alt 30 , but i was still hcv + with a viral load of 9000 .
in feburary this year i started feeling a bit weak and decided that juiceing may be a good idea , i started juicing with strawberries , black and green grapes , carrots , pomegranade , and some lemon .
i was also having my regular supplements that include - milk thistle , vit b / c / and a multi vit withought iron .
after a few days of juicing and feeeling mentally good i added vitamin e to my supplement list - reading that it was a great anti-oxidant .
well i was due for a lft in march and my report came back with ast= 62 and alt 161 . i continued with the juice and the vit e not realinzing that they could be the culprit .
after 2 weeks of checking again my ast was 106 and alt 320 ... and thereafter another week they went up to ast- 116 and alt = 400 , i paniced and though what is it... what is it ..... here im trying to do everything thats good for my body and liver but whats going on .... then thanx to the mystic law of the universe i tumbeled upon this study .
Quote from the article.
"To date, only a limited number of studies have reported finding an influence of ordinary nutrients on hepatitis C virus (HCV) RNA replication. However, the effects of other nutrients on HCV RNA replication remain largely unknown.
Here, using this OR6 assay system, we comprehensively examined 46 nutrients from four nutrient groups: vitamins, amino acids, fatty acids, and salts. We found that three nutrients-beta-carotene, vitamin D(2), and linoleic acid-inhibited HCV RNA replication and that their combination caused additive and/or synergistic effects on HCV RNA replication. In addition, combined treatment with each of the three nutrients and interferon alpha or beta or fluvastatin inhibited HCV RNA replication in an additive manner, while combined treatment with cyclosporine synergistically inhibited HCV RNA replication. In contrast, we found that vitamin E enhanced HCV RNA replication and negated the effects of the three anti-HCV nutrients and cyclosporine but not those of interferon or fluvastatin. These results will provide useful information for the treatment of chronic hepatitis C patients who also take anti-HCV nutrients as an adjunctive therapy in combination with interferon. In conclusion, among the ordinary nutrients tested, beta-carotene, vitamin D(2), and linoleic acid possessed anti-HCV activity in a cell culture system, and these nutrients are therefore considered to be potential candidates for enhancing the effects of interferon therapy.".
link for the above study - http://aac.asm.org/cgi/content/short/51/6/2016
also then i did a little more reading and found this ...
AIM: To elucidate the effect of antioxidants, resveratrol (RVT) and astaxanthin (AXN), on hepatitis C virus (HCV) replication. METHODS: We investigated the effect of recent popular antioxidant supplements on replication of the HCV replicon system OR6. RVT is a strong antioxidant and a kind of polyphenol that inhibits replication of various viruses. AXN is also a strong antioxidant. The replication of HCV RNA was assessed by the luciferase reporter assay. An additive effect of antioxidants on antiviral effects of interferon (IFN) and ribavirin (RBV) was investigated. RESULTS: This is the first report to investigate the effect of RVT and AXN on HCV replication. In contrast to other reported viruses, RVT significantly enhanced HCV RNA replication. Vitamin E also enhanced HCV RNA replication as reported previously, although AXN did not affect replication. IFN and RBV significantly reduced HCV RNA replication, but these effects were dose-dependently hampered and attenuated by the addition of RVT. AXN did not affect antiviral effects of IFN or RBV. CONCLUSION: These results suggested that RVT is not suitable as an antioxidant therapy for chronic hepatitis.
heres the link for the above study - http://www.myhealthfulworld.com/content/an-antioxidant-resveratrol-significantly-enhanced-replication-hepatitis-c-virus
i since have completely stopped taking the vit e and the juice . please note that grapes , peanuts , strawberries and pomegranade all contain high amounts of resvetrol .
I also stopped taking the multivitamin withough iron as it contained vit e ...
i have discussed this topic with a few friends but they dont seem to think resvetrol and vit e can do any harm !!! i wonder !!
but the same hcv community will come down ure throat if u say u had a beer or a steak .... ( i dont drink or eat red meat anymore ) saying that alcohol replicates hcv ... and iron is bad .. u shouldnt even eat spinich ....
well i would also like to add that 2 weeks of no juice and vit e .... and milk thistle 2 times a day have bought my ast from 116 to 96 , and alt from 400 to 275 .
PLEASE MY FRIENDS be carefull of what u eat and drink when suffering from hcv ... saying that " its natural " dosent mean its good for us ... we have a specific disease .... mud is natural too - would we eat it !!!
people without liver disease can eat and drink all that they want ..including mud -;) ..... but not us ,
i may be wrong and do welcome ure inputs .
also before i leave - i need to ask u all a small question .
as i said earlier - i was infected ( not diagnosed ) with hcv 3 years ago , do i need to get a live biopsy done !!! i dont drink or eat red meat and oily food , my ultra sound shows no enlargement ... but i am tired and have fatgue all the time .... yes my liver enzimes are high .. but im pretty sure that the reason behind that is the resveratrol and the vit e tablets which i have stopped taking now . .
thanking u and wishing u all well - await ure inputs regarding the bx .. and hope u all find the above studies helpfull.
pacman
Now this study is the perfect example you cant believe "everyting you read on the web"
show me the money
SPEAK TO ME
"I've been mad for ****-ing years, absolutely years, been over the edge for yonks, been working me buns off for bands..."
"I've always been mad, I know I've been mad, like the
most of us...very hard to explain why you're mad, even if you're not mad..."
show me the money
SPEAK TO ME
"I've been mad for ****-ing years, absolutely years, been over the edge for yonks, been working me buns off for bands..."
"I've always been mad, I know I've been mad, like the
most of us...very hard to explain why you're mad, even if you're not mad..."
i don't buy it and think it is wrong information. Resveratrol is a great "Proven" supplement.
i also remember HR saying it was one of the key supps he recommends to HCV patients.
i also remember HR saying it was one of the key supps he recommends to HCV patients.
When HepatitisResearcher was writing here he was a great proponent of resveratrol along with curcumin for their anti-inflammatory / anti-fibrotic properties. I've taken resveratrol ever since he advised it, so I am a lot dismayed by this study. Now I don't know what to think.
Thanks for posting
dointime
Thanks for posting
dointime
Thanks for that info. What dose of Vit E were you taking?
alek07
alek07
dont know about this...i was reading your link to the study and it didnt mention how many patients or any other info like age,sex...nothin...wjats up with that./...and its this a govt run site you posted in that link?..something looks fishy too me
Thanks for the article. As with all things, each of us must weigh the pro's and con's of what we choose to do. I, myself, will continue to eat my peanut butter, because I like and enjoy it. I will continue to use my Cocopure which contains a small amount of Resveratrol, because I like it. I look at the whole picture and not just what it might do to my liver. My heart is also a part of my body and the Resveratrol is good for my heart, so I weigh it..., little bit bad for my liver, or a little bit good for my heart. You know? Every day, one study says Coffee-bad.. and then, Coffee-good and then, a person gets like, well ??? what am I supposed to do. It sometimes can drive you a bit nuts..., no pun intended!! I'm hoping that I am not coming across like I'm getting on to you for posting this because I'm most certainly not! It's always great to make our decisions with all the applicable information we can gather. Thanks again! Susan400
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