I started taking Sinemet about 3 months ago and my blood sugar levels, insulin resistance are all over the map. In the morning I fight to get my BSs down and now, in the afternoon, I often have BS crashes into severe hypo territory. I've been to the emergency twice these past two weeks - a week ago Friday with hyper, ketones and this last Friday with a severe hypo with 5 units still active!!! Apparently, the Sinemet and Parkinson's mess up the hormone releases in the circadian rhythm, especially norepinephrine and cortisol, both of which increase glucose levels.