I am new to the group and I am confused. For 15 years I have had recurring episodes of vertigo, balance/walking problems, which would go into complete remission. I developed depression and anxiety attacks, but my episodes would suddenly hit when I was not depressed or anxiousl I bagan feeling very fatigued to the point I had difficulty driving to work (45 mi one way), became so fatigued and then depressed I had to quit my job. I was unable to leave my bed for weeks. I began seeing a psyche who blamed it all on mental chemical imbalances. this too, went into remission. Suddenly in March of 2012 the fatigue hit with chest pain. I had a full heart work up, all ok. The summer was VERY hot and last August I got up with sudden vertigo, violent headache, double vision nausea. Went to the doc and was hospitalized with supposed inner ear infection. I was back in the hospital a week later and they sched a neuro appt. I had another mri (previous mri's had shown some lesions), and I had a LP and multiple blood workups. The LP showed O-bands and I was dx with MS. I saw an MS specalist, who ruled out MS and ran various tests for nerve and inner ear. Saw a neuro ophthalomologist who could not determine the cause of my double vision. nobody knew why I had fatigue and extreme muscle weakness or imbalance. Things have improved but not gone into remission as before. I have made two trips to Mayo in Rochester - 10 hrs each way.. I am trying to live a normal life but if I have a busy day, or do too much physically, I spend several days recovering. Some days I can barely climb the stairs without resting and have fallen in my own home from imbalance and weakness. Recently for several days I experienced tremors, extreme muscle and limb twitching. I am waitng to hear from Mayo neuro. However, I can go online and check lab results and doc notes. The lab results show 4 or more O bands but low IGg. However doctors notes say normal CSF, no evidence for MS or paraneoplastic disease. No malignancy or lymphocytes. So I am researching everything. I found a reference to Devics disease but I can't correlate the O Band findings with the low levels of IGg. Does anyone have any ideas? All suggestions appreciated I have also found reference to thymus disorders.