child pough-B & C in HCC and Nexavar.

gupta47

Hi,
My question is if the patients of HCC is in between Child pough B or C then can these type of patients to be putted on Sorafenib(Nexavar) treatment? if yes then what will be the recommanded dose for these score of patients?.

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kflow

With the increase in dosage from 200 mg x twice daily to 400mg x twice daily - what are the side effects and does it really help when patient is diagnosed with Child Pugh B to C?

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MEDICAL PROFESSIONAL

Fernando Roque, MD

Hi. For liver cancer patients who are Child-Pugh class A or B, there is no need to adjust the dose of Sorafenib (source: Nexavar product information). For those who are Child-Pugh class C and who have severe impairment in liver function, caution must be exercised in giving Sorafenib as this drug is primarily metabolized by the liver. At present, there are no clinical trials which have studied the use of Sorafenib in Child-Pugh class C patients, so we don't know how the drug will affect this patient population. The recommended dose of Sorafenib for liver cancer patients with advanced disease and who have a Child Pugh class A or B is 400 mg twice daily.

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