I'm on 60mg. Cymbalta and have been for probably two years now. It helps somewhat for my depression but not good enough. I'm also bipolar, the depression holes being the worse. I have periods of intense creative release, feeling on top of the world, great self esteem. sleeping well, (no extravagent spending) self worthy, etc., etc. Then I slip into the darkness. A switch has been turned off. Energy drained, feel worthless, I don't shave, shower, I can't even speak a few words to anyone.I feel like a failure and will never make anything out of myself. I sometimes cry out, "I don't feel good, what's wrong with me?!" I'm totally depressed. I eventually start to feel better and everything is fine. My doc started me on 300mg. lithium at night and will increase to 600 in a week. I'm already sleeping better I feel. Has lithium worked for anyone and about how long does it take for your mood to even out?