You need to make an appointment at your vet for her ASAP. There are a couple of things that it could be and there is no way to tell which one without being seen by a vet.
My first thought would be that she has a urinary tract infection, possibly even severe enough to involve the kidneys. Hopefully it's something that a course of strong antibiotics will knock out. Please keep us updated!
Ghilly
I would be taking her to see her Dr. it could be a uti if blood in pee but not sure about the rest. keep us up-dated