In February, I had a cortisone shot for shoulder pain. Had one some years ago and it worked wonderfully. This one did not work. The pain actually seemed to move to a different place in my shoulder. I am in PT for assumed bicep impingement. In the week after my injection, I had diarrhea so bad that I lost 4 pounds in a week. I also started having severe nocturnal leg spasms. And pain just under my right side ribs when lying down in bed and turning over (pain!!!). The diarrhea abated a bit but is now back in full fashion. I keep the leg cramps at bay with 1 hour of compression massage before sleep. I just feel so generally unwell. I have to be really careful about what I eat now and it is hit and miss. This all started with the cortisone injection. Is it possible that a cortisone injection could have adversely affected my body in this way?? I have regular colonoscopies, recently had an internal ultrasound by my OBGYN, I have yearly bloodwork....all is good.