Aa
HIV COMBO TEST
Hi all, just a quick 1, is HIV COMBO TEST a valid test?
Doctors here are saying that it's a very reliable (if not 'conclusive') test at 28 days.
Is P24 really a good indicator in determining a person whether infected or not?
How many days does the P24 antigen exist in a person's blood? like, 2 weeks to 4 weeks then it disappears?
How infectious is a newly infected person? Is it that a person got infected TODAY and can start infect others TOMORROW?
Doctors here are saying that it's a very reliable (if not 'conclusive') test at 28 days.
Is P24 really a good indicator in determining a person whether infected or not?
How many days does the P24 antigen exist in a person's blood? like, 2 weeks to 4 weeks then it disappears?
How infectious is a newly infected person? Is it that a person got infected TODAY and can start infect others TOMORROW?
"P24 antigen is present in detectable quantity and once the detectable amount of antibody is formed, the P24 antigen fades away."
if the Ab form later like in 7wks, then we can still use P24 and test +ve in wks 6.
is it right?
if the Ab form later like in 7wks, then we can still use P24 and test +ve in wks 6.
is it right?
COMMUNITY LEADER
Yes, IV gen antibody test, indeed is a valid and approved test. The combo test detects antibodies and P24 antigen simultaneously.
The working mechanism of this test is very intelligent, a IV gen antibody test is at it's optimum 28 days post exposure.
Now let's understand how it works - The AB detection of the test is a normal III gen antibody test. For a person who has acquired the virus sero-converts 7-14 days post exposure. 7 days post sero-conversion a normal individual would almost always test positive. Meaning - Should test positive by the next 7 days, the calculation comes to 21 days, factoring in a buffer of 7 more days the total calculation comes to 28 days, hence a negative AB on the 28th day is very encouraging.
Now on the other hand, the AG detection of the test looks for the P24 antigen in the body. For a person who has acquired the virus is sero-converting or has already sero converted however, the detectable amount of antibody has not yet been formed, the P24 antigen has a good chance of being detected.
The information that you have seeked is true to a good extend because during the formation of detectable amount of antibodies, P24 antigen is present in detectable quantity and once the detectable amount of antibody is formed, the P24 antigen fades away. Hence, to sum up the whole thing a negative on a IV gen test at 28 days only indicates a negative at the 12th week,
The working mechanism of this test is very intelligent, a IV gen antibody test is at it's optimum 28 days post exposure.
Now let's understand how it works - The AB detection of the test is a normal III gen antibody test. For a person who has acquired the virus sero-converts 7-14 days post exposure. 7 days post sero-conversion a normal individual would almost always test positive. Meaning - Should test positive by the next 7 days, the calculation comes to 21 days, factoring in a buffer of 7 more days the total calculation comes to 28 days, hence a negative AB on the 28th day is very encouraging.
Now on the other hand, the AG detection of the test looks for the P24 antigen in the body. For a person who has acquired the virus is sero-converting or has already sero converted however, the detectable amount of antibody has not yet been formed, the P24 antigen has a good chance of being detected.
The information that you have seeked is true to a good extend because during the formation of detectable amount of antibodies, P24 antigen is present in detectable quantity and once the detectable amount of antibody is formed, the P24 antigen fades away. Hence, to sum up the whole thing a negative on a IV gen test at 28 days only indicates a negative at the 12th week,
just to share this with everybody, take a look at the 3rd page of the slides.
http://www.slideshare.net/bishorvi/aidshiv-testing-methodology
P24 peak between 3rd -4th week.
Antibody peak between 5th - 6th week and it starts DECLINING?
anybody has any opinion on this?
http://www.slideshare.net/bishorvi/aidshiv-testing-methodology
P24 peak between 3rd -4th week.
Antibody peak between 5th - 6th week and it starts DECLINING?
anybody has any opinion on this?
Have an Answer?
You are reading content posted in the HIV Prevention Community
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.
Can I get HIV from surfaces, like toilet seats?
Can you get HIV from casual contact, like hugging?
Frequency of HIV testing depends on your risk.
Post-exposure prophylaxis (PEP) may help prevent HIV infection.
