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Help me with my results please
Hi,
I'm 27 years old male from Middle East. I was diagnosed before 12 years with Hepatitis B.
I've done some test this year and my results are listed below. My doctor advised me to do a liver biopsy to decide if treatment is appropriate.
-------------------------------
HBs Ag: Positive
HBe Ag: Negative
Anti- HCV: non-reactive
HBV DNA (PCR): 72080 copies/ml i.e. 12385 UI/ml
Alfa FETO: 1.3 ng/ml
ALT: 64 u/L
Total BILIBURN 1.27H mg/dL
---------------------------------
Do I really need the biopsy? Is my case severe...? I really don’t know what to do. Please help me
I'm 27 years old male from Middle East. I was diagnosed before 12 years with Hepatitis B.
I've done some test this year and my results are listed below. My doctor advised me to do a liver biopsy to decide if treatment is appropriate.
-------------------------------
HBs Ag: Positive
HBe Ag: Negative
Anti- HCV: non-reactive
HBV DNA (PCR): 72080 copies/ml i.e. 12385 UI/ml
Alfa FETO: 1.3 ng/ml
ALT: 64 u/L
Total BILIBURN 1.27H mg/dL
---------------------------------
Do I really need the biopsy? Is my case severe...? I really don’t know what to do. Please help me
>>>Means your body is trying to fight off HepB and become immune.<<<
No so in chronic HepB. Seroconversion means that there is a response by your immune system towards part(s) of the virus, in this case the eAntigen. If successful and your immune system establishes control over the eAntigen, the majority will be neutralized. So if your eAntibody gains the upper hand and it eventually becomes positive. However, you still have HepB (since samarm case is a chronic one) because seroconverting from surface antigen to surface antibody almost never happens (only happen in about 1% of chronic infections per year).
No so in chronic HepB. Seroconversion means that there is a response by your immune system towards part(s) of the virus, in this case the eAntigen. If successful and your immune system establishes control over the eAntigen, the majority will be neutralized. So if your eAntibody gains the upper hand and it eventually becomes positive. However, you still have HepB (since samarm case is a chronic one) because seroconverting from surface antigen to surface antibody almost never happens (only happen in about 1% of chronic infections per year).
What is seroconverting?
Means your body is trying to fight off HepB and become immune.
Means your body is trying to fight off HepB and become immune.
There could also be a second possible explanation other than an active e-negative disease.
If you were infected at birth, 27 is early for eSeroconversion. This could mean that you are still in the process of seroconverting, despite your e status. Those in this phase tend to have fluctuating DNA and ALTs. Monitor it closely with a series of labs and see how it goes. Good luck.
If you were infected at birth, 27 is early for eSeroconversion. This could mean that you are still in the process of seroconverting, despite your e status. Those in this phase tend to have fluctuating DNA and ALTs. Monitor it closely with a series of labs and see how it goes. Good luck.
You mean these are your second labs ever in 12 years? Its recommended that you do labs about every 6 months.
If you go to the Hep C board they talk about liver biopsy a lot there and the verdict is that it is not a big deal.
If you go to the Hep C board they talk about liver biopsy a lot there and the verdict is that it is not a big deal.
You don't need to have a "severe" case to get a biopsy. A biopsy is just a way to get a look at what is really happening to your liver. Its really the only way to know that is widely available at this time.
You ALT is mildly elevated which could indicate liver inflammation and cell death and your bilirubin I guess is high (indicated by the H). The bigger issue is that you are e-antigen (HBe Ag) negative but your viral load is high for e-negative. That could indicate that the virus has escaped your body's immune control and that treatment is required.
It is fairly standard to do a biopsy before inititating treatment. Have you been doing regular labs to this point?
You ALT is mildly elevated which could indicate liver inflammation and cell death and your bilirubin I guess is high (indicated by the H). The bigger issue is that you are e-antigen (HBe Ag) negative but your viral load is high for e-negative. That could indicate that the virus has escaped your body's immune control and that treatment is required.
It is fairly standard to do a biopsy before inititating treatment. Have you been doing regular labs to this point?
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