Can anyone share their stories?

[Classify]

Hello, here is my lab results for this year 2014:

March 20, 2014 – On Baraclude treatment

Hepatitis B surface antigen-Q Reactive A Non-Reactive
Hepatitis BE ANTIBODY Reactive A Non-Reactive
Hepatitis BE ANTIGEN Non-Reactive Non-Reactive

Hepatitis B Virus DNA,QN, Real Time PCR

Test               Result Flag Reference
Hepatitis B Virus DNA <20 IU/mL H <20
*Detected below the limit of Quantitation
Hepatitis B Virus DNA <1.30 log IU/mL H <1.30
*Detected below the limit of Quantitation

10/10/2014 – Stopped Baraclude treatment
AST – O 23 U/L 4-40

ALT – O 28 U/L 4-41

Hepatitis B Virus DNA, ON, Real Time PCR

Test Result Units Flag Reference Range
Hepatitis B Virus DNA <20 IU/mL <20
Not Detected
Hepatitis B Virus DNA <1.30 Log IU/mL <1.30
Not Detected
(From 10/5/2014 – present I stopped taking Baraclude due to Doctor changes, etc.)

12/4/2012 – Stopped Baraclude Treatment for 2 months
AST- Normal
ALT-Normal
Hepatitis B Virus DNA, ON, Real Time PCR

Test Result Units Flag Reference Range
Hepatitis B Virus DNA <20 IU/mL <20
Not Detected
Hepatitis B Virus DNA <1.30 Log IU/mL <1.30
Not Detected

With my new blood test result as above, my liver specialist had recommended me to stop my baraclude treatment.  
I wonder had everyone on this forum ever got cure from a situation similar to my?  Thank you.

[stef2011]

increase vit d3 dose so that ipth stays around 10-15pg/ml

it looks like your hbsg was lowering when low ipth, remember when your pth gets to 15-20pg/ml it means you are fully vitamin d sufficient, vitd25oh alone doesn t indicate sufficiency.lets see if it goes down again

remember no dairies in your diet and 2.5l of water with calcium less than 10mg/l daily

[bill0202]

my update

2015.6.10 : ast24, alt27, qhbsag 53.18iu/ml, d3(25OH) 82.2ng/ml(30-100), PTH-i 25.5pg/ml(15-65),
Ca 9.0mg/dl (8.5-10.1).

2015.4.10 : ast32, alt28, qhbsag 38.31iu/ml.

2015.3.3 : ast30, alt32, qhbsag 64.47iu/ml, d3(25OH) 74.4ng/ml(30-100), PTH-i 30.7pg/ml(15-65),
Ca 9.01mg/dl (8.5-10.1), free Ca 4.96mg/dl (4.48-5.28).

[stef2011]

yes it is normal for hbvers, the receptors are mutated or resistant to vit d

[stef2011]

very good results, increase vit d3 to 30.000-40.000iu daily since we have seen pth is still elevated and calcium normal

retest intact pth in a month or two.while on this vit d3 dose avoid any dairies and nuts, drink 2.5l of water with low calcium (less than 10mg/l), this is to stay on safe side with calcium, best avoid these foods which contains too much calcium

i think you will clear by etv, only a matter of time

[sorte]

stef is it normal that his vit d3 went up twice and PTH almost didn't moved or it starts to move with some delay ?

[sorte]

good results ! I assume that HBV DNA is und now ?
hope you'll be HBs- soon :)
how long you took vit d3 to obtain that level and from what level you started ?

[flyinsky]

Good results Hope you cure

[flyinsky]

Good results Hope you cure

[bill0202]

update : qhbsag from 91.5 down to 64.5iu/ml in three months

Baseline ( ETV STOP after 6 years of daily 0.5mg therapy)
Dec.31,2013:  ast 31, alt 37, HBV-DNA <6 iu/ml, qHBsAg 27.72 iu/ml;

CHB relapse, ETV 0.5mg Restart (New Baseline)
Sep.17,2014: ast 781, alt 1,524; HBV-DNA 169,000 iu/ml, qHBsAg 2,707 iu/ml.

Dec.12,2014: ast38, alt46, qhbsag 91.47iu/ml, D3(25OH) 38.5ng/ml, PTH-i 31.5pg/ml, Ca 9.1mg/dl.

Mar.3,2015: ast30, alt32, qhbsag 64.47iu/ml, d3(25OH) 74.4ng/ml(30-100), PTH-i 30.7pg/ml(15-65),
Ca 9.1mg/dl(8.5-10.1), free Ca 4.96mg/dl (4.48-5.28).

ETV responce well, next qhbsag after 3 months may reach 45iu, i hope.

[stef2011]

it could also be the effect of being back to etv this said vit d will surely help fasten any immune process and i really hope will clear hbsag.

[bill0202]

(go for vit d3 20.000iu daily, you must reach a level of vitd25oh that makes intact parathomone

low range of normal like 10-20pg/ml .........after about 6 months of stable low pth there should be a

big boost of immune function
are you already back on etv? )

my CHB relapse, restart ETV

Dec.31,2013:  stop ETV
ast 31, alt 37, HBV-DNA <6 iu/ml, HBsAg 27.72 iu/ml;

Sep.17,2014: CHB relapse, restart ETV for three years
ast781, alt1,524, HBV-DNA 169,000 iu/ml, HBsAg 2,706 iu/ml, HBcIgM-negative.

Dec.22,2014: Current status
ETV0.5mg + Simvastatin 20mg + 10,000iuD3 (Dec.8 since) + topless sunshine 45min.
ast38, alt46, HBV-DNA 27.2 iu/ml, qHBsAg 91.47 iu/ml, creatinine 0.9, TBI 0.4,
D3(25OH)38.5 ng/ml, PTH-i (? report waiting) pg/ml, Serum Ca 9.1 mg/dl , Ca ionic 4.68mg/dl.

Stef is right, i will take 20,000iuD3 daily until D25OH reach 85-100ng/ml and low PTH.

[stef2011]

go for vit d3 20.000iu daily, this might help recover some t cell response although with hbsag over 2000iu/ml this will be difficult
this is a must because this helps immune function very much when combo with antivirals or immune therapies but to help you must reach a level of vitd25oh that makes intact parathomone low range of normal like 10-20pg/ml

so start d3, avoid all dairies, drink 2.5l of water daily and make the tests, after about 6 months of stable low pth there should be a big boost of immune function

are you already back on etv?

[Classify]

Thank you for the responses guys.  So my story is that my Dr. did tell me that baraclude is very effective but dangerous to stop, and he did gave me a prescription to buy baraclude here in the U.S.  

When my test results came back he said I have a negativeon antigen or antibody, something like that, since I was too happy and so I did not recalled what he said.  But I guess I was serocoverted.

So today I'm waiting for a phone call from my Dr. so I can ask him to make sure, and request for further testings if I can.  Let you guys know later.

[bill0202]

what blind doctors, pegintf add on or pegintf switch was the correct choice to get rid of hbsag
use tenofovir if you restart, not etv
and when hbsag is very low like less than 100-300iu/ml i would go for peg add on to fasten clearance
A: many thanks steff, i will go for peg add-on when hbsag <180iu/ml. and with the help of simvastatin 20mg and D3 10,000iu daily to boost my immune that in this forum you suggested. thanks again, i just received 10,000iu D3 from UPS US.

[bill0202]

Bill how did your doc stop antivirals and your hbsag was so low. maybe if You continue it.you achieved hbsag-.did you change the doc?
A: stop ETV was my dicision, my public medcare only cover 3 years, now with same doc already started second ETV treatment that also cover 3 years for free. hbsag - is my dream, after reading posts this forum i will do interferon add-on when hbsag <180iu/ml.
bill0202

[bill0202]

Part III: history
1. When you first started taking ETV, were you HBeAg positive or negative?
A: ETV1st start in Aug 2007 with HBeAg negative, and Anti-HBe (+) positive.
2. If you were HBeAg negative when you started ETV, what was your history before you started ETV?
A: CHB and/or fatty liver history more than 30 years.
1st hbsag test in 1979 positive, GOT/GPT abnormal;
1st hbeag test in 1996 negative.
ETV 1st start in Aug 2007 when HDV-DNA 30,000 copies/ml; AST 45 / ALT 74.
history before 2007 ETV started: GOT somewhere 35-55, GPT abnormal 40-75.
ALT abnormal most the time from 1979 to 2007 due to CHB and/or minor to moderate Fatty liver.
3.It does seem to me that you have re-gained strong T cell immune function during your 6 years of ETV treatment.
A: very encourage, thanks.

[StephenCastlecrag]

Many thanks for the new information. I am so glad you seem to responding very well to re-treatment with ETV. You had such a strong ALT flare in response to a relatively moderate rise in hbvdna. It does seem to me that you have re-gained strong T cell immune function during your 6 years of ETV treatment. There must be other markers, other than qHbsAg, that can allow us to predict when we can successfully stop NUC treatment.
All the best, do keep us informed.

[bill0202]

Part I: CHB relapse
after stop ETV therapy for 3-6 month, CHB relapse,
Dec.31,2013: day 0 stop ETV after 6 years of ETV
alt 31, ast 37, HBV-DNA <6 iu/ml, HBsAg 27.72 iu/ml;
Mar.31,2014: GOT(ast) 17, GPT(alt) 27, HBV-DNA 40 iu/ml, HBsAg 322.8 iu/ml;
Jun.28,2014: GOT(ast)139, GPT(alt) 259, HBV-DNA 104,000 iu/ml, HBsAg 287.7 iu/ml;,
Sep.17,2014: GOT(ast)781, GPT(alt) 1,524, HBV-DNA 169,000 iu/ml, HBsAg 2,706 iu/ml, HBcIgM-negative. before stop, i take ETV for 6 years, i am hbeag negative.
Sep.19,2014: GOT(ast)437, GPT(alt) 1,057, t-bil 1.3

Part II: Current status
ETV Restart: Sep.17,2014, my medcare will cover for 3 more years, will be stop in Sep17,2017.
Sep.17,2014: GOT(ast)781, GPT(alt) 1,524, HBV-DNA 169,000 iu/ml, HBsAg 2,706 iu/ml, HBcIgM-negative; total bilirubin 1.5mg/dl; hbeag negative, hbeab positive;
Sep.22,2014: GOT(ast)285, GPT(alt) 712, t-bil 1.5;
Sep.29,2014: GOT(ast)142, GPT(alt) 349, t-bil 0.8;
Oct27,2014: GOT(ast)40, GPT(alt) 58, t-bil 0.4;
next analysis
Dec.22,2014: GOT(ast)?, GPT(alt) ?, t-bil ?, HBV-DNA?, qhbsag ?.

[stef2011]

and when hbsag is very low like less than 100-300iu/ml i would go for peg add on to fasten clearance

[stef2011]

what blind doctors, pegintf add on or pegintf switch was the correct choice to get rid of hbsag

use tenofovir if you restart, not etv

[flyinsky]

Bill how did your doc stop antivirals and your hbsag was so low. maybe if You continue it.you achieved hbsag-.did you change the doc?

[StephenCastlecrag]

Thank you for sharing your data. It certainly makes a very strong case against stopping. I notice you are from Taiwan, Taiwan is one of the few countries where liver specialists(e.g. Dr Yun-Fan Liaw) are very open to stopping antivirals. If you don't mind I would like to ask several questions:

1. When you first started taking ETV, were you HBeAg positive or negative? If you were HBeAg positive when you first started ETV, how long did it take to e-seronconvert after starting ETV? If you were HBeAg negative when you started ETV, what was your history before you started ETV?
2. Are you now on any antiviral and and what is your latest ALT, hbvdna and qHBsAg?

Many thanks in advance.

[bill0202]

totally agree with steff n flyinsky, after stop ETV therapy for 3-6 month, my CHB relapse,
Dec.31,2013: day 0 stop ETV after 6 years of ETV
alt 31, ast 37, HBV-DNA <6 iu/ml, HBsAg 27.72 iu/ml;
Mar.31,2014: alt 17, ast 27, HBV-DNA 40 iu/ml, HBsAg 322.8 iu/ml;
Jun.28,2014: alt 139, ast 259, HBV-DNA 104,000 iu/ml, HBsAg 287.7 iu/ml;,
Sep.17,2014: alt 781, ast 1,524, HBV-DNA 169,000 iu/ml, HBsAg 2,706 iu/ml, HBcIgM-negative.
before stop, i take ETV for 6 years, i am hbeag negative.
bill0202

[SafiSifa]

Hello,

I am cured with Baraclude in only 12 months. Although I am totally cured, I am still on Baraclude treatment.

You should continue treatment

See my results: http://www.medhelp.org/posts/Hepatitis-B/My-All-Test-Result-After-12-Months-Treatment-of-Entecavir-I-am-cured/show/2355051

See my story: http://www.medhelp.org/posts/Hepatitis-B/Urgent-Advise-for-Entecavir-Usage/show/2044528