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Chronic HBV

Is chronic Hepatitis B is curable??
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again, veteranB, there you go with the misinformation.  I gave 10 ml of blood and got my HBsAg no problem.  My doctor did not refer me for biopsy, which I wonder why if it is such a "lucrative" market.  

Regarding clinical trials, you must not understand how they work.  Phase I trials are always done on a small cohort.  You are not going to subject more people than necessary to a drug with unknown effects.  You save that for Phase II.

I am curious veteranB, what have you done to move our research and cure forward?  Have you gone out and petitioned Replicor, Gilead, or others?

If you spent as much time trying to solve the problem as you do ranting on these message boards about how much the government and drug companies are out to get you, we'd have a cure by now!
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Avatar universal
So how can in this current medical system anything be done when they only think about money and making the shareholders happy. Look at the wording they use..

Investment Commentary

Abbott's hepatitis C trial announcement evidently sent shivers down the spines of Gilead Science (NASDAQ: GILD) shareholders. Traders must have feared that Gilead ran the risk of being overtaken in the race for supremacy in the worldwide market for new hepatitis C treatments. After all, the stakes are high, with the market expected to reach $20 billion by 2020, according to Bloomberg.
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It has come to the point that we as patients maybe better off just cutting deals with these individual companies and bypassing the doctors and all the legal bs that follows?

But will they do it?  The question is for Replicor and all you recruiters for clinical trials and new tests that watch us here ;)
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Avatar universal
regarding clinical trials I also don't agree with the current policy regarding deadly viruses such as HBV..

They are saying they want to help! So why are the clinical trials take so long? And have so few people. Replicor why it is the case with your drug?

Another example. GS9620  trial in San Diego only took 9 people. How can this be serious?

They say they need people and want to help? A person makes arrangements with them in spring. Then they start the trial, forgetting to tell they did, and tell you well you have to be on TDF for three months before entering. Well Duh.. why didn't you say it ahead of time. The criteria was to be fully DNA suppressed and what difference does it make if one is on ETV, Hepsera, Tyzeka vs TDF. These are all me 2 drugs.  That is an example of how they treat people and who works there with what kind of medical ethics.

Getting a surface antigen quantitative test.. well yes it is possible kind of an hush hush bases if you agree to give 700ml of blood to this one company. And they don't told you straight forward what exactly you will be doing. So on a continuous bases to get this test you have to unload 700ml of blood each time. And oh yes they will give you $50 for it. Kind of insulting when you can't by a decent lunch for two in shiny Socal for that.

This is what really what is going around HBV treatment.. and have not even began writing about what insurance companies do how much pressure they put on the doctors to not give you this or that test. So they can keep their cost down.  

What medicine has become today what is done behind scenes is totally amoral. There is no regard, and no respect for HBV patients. All this is incredibly frustrating, and all this is legal btw to do.
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Avatar universal
essentially what we have to live through and suffer from is a slow passive eugenics till the time we either all die, or our body clears hbv on its own with the help from above or till they will develop a cheap to make cost effective drug. That wont burden the interests of insurance companies as well.

Something like this may be 10 years away. By that time chronic HBV population will shrink to almost none in industrialized countries because of 100% vaccination, but for third they don't care really. And we will be dieing off not only from effects of HBV but the adverse affects that antiviral chemotherapy has for us. which is being also hidden from the public.

That is how they those in power look at this issue. They see a real public threat in HCV that is why they have such a great treatment for it.. For us there is nothing like that even though better treatment combos are available..

Interferon + Antiviral
Zadaxin + Antiviral
Interferon + Zadaxin + Alinia
Molyxan + Interferon

also sequential treatments that stef2011 is talking about..

Why all this is not being done on a massive scale? Simple answer is cost.

Why Dr.Gish the world renown researcher is not using this and doing clinical trials that are only sponsored by the drug companies? This is product testing. You call this cutting edge > like it should be in the USA really. I mean really, how can we not be angry?! This is is pathetic and ridiculous and shame on them.

HBV is treatable even now with what we have today. It is tough treatment, some people may need 90weeks of Pegasys with something because no one drug works alone. But the know how is there.
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Avatar universal
Well,  it is exactly the same thing as why we don't have FibroScan and surface antigen quant test available here - test 2 potentially negatively impacts the antiviral market. Test 1 - interferes with the gastroenterologist's lobby that likes to do biopsies left and right.

You have to remove your pink glasses and look at things the way they are. If they release this drug > what will the whole "lucrative" HBV will do - it will disappear.  

So this is definitely a political and financial issue first and for most.

The same thing with HIV treatment. Do you hear bone marrow transplants being offered or even told to patients by their doctors? That this is treatable and not a death sentence? No, right. Despite 4 people world wide being cured of it. What do insurance companies say already  - investigation and they won't pay for it.

it is the same reason we have clinical trials of only 10-12 people at the time. Done very secretively too - also done to control the info if the drug is a success. So these companies can discuss in their board room meeting about the cost vs profit of making and releasing this drug and how it will affect the market. People that make development of  cures, their companies are trading on the stock exchange. And HBV is a market first and most to them. Us hbv patients they think of as a expandable gray matter.

The question is how can doctors go with this system. That is a really big question. What about the Hippocratic oath that they take?

Logically and morally yes Replicor should go public with their discovery. That is why I say all of us need to write to them, we need to start a massive internet campaign. And you my friend need to get Dr.Gish involved in this too since you go see them other there.  
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Avatar universal
I just don't see it.  If you owned the keys to a bank vault worth billions, maybe trillions of dollars, why would you sell it to someone for pennies on the dollar?
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