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What is the latest on Replicor?
http://replicor.com/pipeline/
Potential HEPB cure.
I believe soon Replicor will deliver but, since it is a privately held company I don’t know if they are well funded to get to the finish line faster. If many of us band together and invest in Replicor we may have the cure faster. Who is with me? Not intended to be financial advise just my opinion
Potential HEPB cure.
I believe soon Replicor will deliver but, since it is a privately held company I don’t know if they are well funded to get to the finish line faster. If many of us band together and invest in Replicor we may have the cure faster. Who is with me? Not intended to be financial advise just my opinion
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I believe Replicore will get approved if not here in the USA but EU/Canada or somewhere in Asia. I believe at the moment Replicore is doing something significant in France and if successful that alone will change a few naysayer's minds and maybe soon they will get approved in the EU.
by the way, you have Great insight and I Thank you
by the way, you have Great insight and I Thank you
You need to meet certain income or networth requirements to be able to invest in replicor.
I am considering the investment, but would be open to explore gofundme option for pooling up the money as well, again not sure if that is feasible.
I am considering the investment, but would be open to explore gofundme option for pooling up the money as well, again not sure if that is feasible.
2 Comments
count me in.
I think we need to write a letter to the politician to fund for more money for HBV. https://www.hepb.org/donate. It will take a lot more money than what most of us.
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Many of us have followed Replicor for over 10 years, your suggestion was taken seriously very early on, but came to nothing, the main reason being we just didn't have enough money and most hbvers were not interested, especially when it comes to putting up money.
Replicor's NAP is now accepted by most HBV specialists and researchers. But there are still two main objections: 1. the still unknown mechanism of how NAP work, and thereby hard to gauge potential side effects. Replicor has done a lot of work in this area, but outside help and money should help; 2. the ALT flare experienced during the functional cure induced by NAP. Conservative HBV doctors, such as Dr Anna Lok, are still cautious. Replicor has concluded that the ALT rise is mostly transient. Further research, with money and clinical studies, may be able to characterize this rise ( which I believe to be caused by the body's rekindled immune systems to control infected HBV liver cells due to the reduction of serum HBsAg).
Will Replicor do another clinical trial as promised in the USA? Dr Andrew Villiant suggested the delay was due to COVID 19 and not a problem with the subcutaneous form of REP2139.
Will FDA ever approve REP2139? My opinion is that it will not unless FDA has a change of culture, a change that is very much needed. At the moment, FDA favors the big pharma in granting quick approval( see how fast it approves the various COVID-19 vaccines) but drags its feet when smaller companies are involved, citing safety concerns, especially with RNAi, RNA drugs. Also, FDA prefers drugs that have been through animal studies, not human studies. Also, FDA is not unknown for some of its quirks, for example, its very unreasonable quirk against approving monoclonal HBsAg antibodies, which was developed many years ago but died due to a very stringent request for a type of clinical trial.
So what is the future of Replicor's NAP? I don't know. Personally, I hope Replicor is resisting takeover by big pharma because it wants to make sure its drugs are affordable for HBV patients. Replicor is very resilient.
What about other functional cure drugs? Capsid formation inhibiting drugs, like type II CpAM, will not provide a cure but may serve as antiviral drugs. Existing RNAi drugs are not potent enough. However, a recent research paper suggested long-term treatment by NA can reduce or eliminate the cccDNA pool. Therefore patients may be cured, because they have no more cccDNA, but they are still HBsAg positive due to HBsAg produced from integrated hbvdna. But HBsAg is just a protein. So are patients cured? I also believe in monoclonal HbsAg antibodies as possible drugs to reduce low-level serum HBsAg, thereby providing a window for vaccines, administered in a different way, to rekindle the body's immune functions.
These are just my personal opinions.