Chronic Hep-B still active after 5 years

[shahzadsaahil]

I am a patient of Chronic Hepatitis B. I have been suffering from this disease since January 2009. I am constantly following up my disease since its diagnosis. I have undergone through a pegasys injection + Hepsera Tab therapy for one year from May 2009 to April 2010. I have taken Entacavir 0.5 mg  from May 2010 to October 2013. and i have been taking oral anti viral tenofo-B from November 2013 to April 2015 and in May 2015 Doctor prescribed me to start centaurus (Entecaver) in addition with Tenofo-B. My Medical history includes HBV DNA by PCR Quantitative is under 10 IU/ml after 5 Years. But HBeAg is still Reactive 27.09 and Anti-HBe is Non-Reactive 3.3. My ALT is 32. My RBC is 4.5 * 10^12/l, My Hb is 13.8, My Platelet Count is 215 * 10^9/l.

[fighter_fighter]

it is but it depends on the doctor. personally i want to continue and check hbsag quantitative and lets see how it works directly to HBV. Now all other tests in me is normal i will focus on hbsag quantity and if it showing decline I will continue to take my antiviral because some cleared (the lucky ones) with antiviral therapy. :) Some needs peg inteferon with very low hbsag count.

[pong58]

Is it possible to stop tdf after you hbe seroconvert?

[fighter_fighter]

hmm somehow i would think im in immune clearance phase at the time of e-seroconversion. I am genotype A and 30yrs old. here some details:

October 2014:
HbeAG+
AntiHbe-
HBV DNA 118million
ALT=400+
AST+300+

November 2014:
HbeAG+
AntiHbe-
HBV DNA 7000+
ALT=300+
AST=200+

December 2014:
HbeAG-
AntiHbe+
HBV DNA 141
ALT=120
AST=50

June2015:
HBV DNA undetected
ALT=44
AST=36

So I am not sure if its just coincidence that when I starting taking Viread helps the e-seroconversion but looks like it help ti improved all numbers.
Now i am waiting for my hbsag quantitative and see how it works directly to HBV.

[StephenCastlecrag]

Most patients e-seroconvert before the age of 40, genotype C generally takes longer time. NA antivirals only inhibit replication of HBV, that is indicated by low or undetectable serum hbvdna, leading to reduction of inflammation, hence normal ALT and little damage to the liver.

Natural e-serconversion occurs during Immune Clearance phase, marked by flares in ALT. If the period of Immune Clearance is long, that is, frequent flares of ALT without e-seroconversion, liver will be damaged as indicated by fibrosis. So whether to treat or wait during Immune Clearance phase is often a difficult decision to make. These days, doctors can be guided by Fibroscan - if serious fibrosis is detected, then treat.

[fighter_fighter]

And by the way I never take interferon treatment., So what makes my e-seroconversion in less than 3months? I only take viread that time and i test this HbeAG and anti Hbe every month. Also i developed anti Hbe.

[fighter_fighter]

hi i e-seroconverted to during my treatment in less than 3months by Viread. I am e-positive since 2009 and from there i only take lamivudine for 3months and stop and ignore. I just resumed to have attention on my HBV last October 2014 and im still e-positive. Meaning I am e-positive for almost 5years wthout seroconverting naturally. And after taking viread become e-seroconverted, now im not sure if its taking Viread or immune system that makes the seronconversion to e.