TAF vs TDF

[Aduiski]

Just read the two abstracts of the EASL conference.
Gilead research results are presented for hbeag negative, as well as for hbeag positive CHB, for 48 out of 96 weeks of treatment.

If presented results are true, it is clear that for hbeag negative CHB, TAF seems to be superior option compared to TDF. Compared to TDF, TAF resulted in significantly higher percentage of patients having normalised ALT after 48 weeks of treatment (50% vs 32%), significantly less loss of eGFR (loss of 1.4 vs 4.7), and significanlty less loss of bone mineral density.

The study is continuing for another 48 weeks...

[Aduiski]

...also...people ho took TDF-based PrEP (not to be infected with HIV) recovered their slightly decreased eGFR kidney function a year and a half after stopping TDF-based prep.

[Aduiski]

Following links from an HIV website shed some more info on both TDF and TAF...
An interesting fact that TDF works good for cholesterol..but not TAF

http://www.aidsmap.com/Tenofovir-alafenamide-works-well-against-hepatitis-B-with-less-effect-on-bones-and-kidneys/page/3051008/

http://www.aidsmap.com/Tenofovir-HIV-PrEP-causes-no-long-term-harm-to-kidneys/page/2854906/

http://www.aidsmap.com/DAD-study-long-term-treatment-with-tenofovir-associated-with-increased-risk-of-serious-liver-disease/page/3028513/

[stef2011]

without hbsag quant or cccdna, intrahepatic hbv data having normal alt is meanless

note that those with abnormal alt and hbvdna undetectable under nucs have more hbsag decline, so we have to see if these percentages of normal alt are really due to more potency

[studyforhope]

It would be good to have the full text of these two abstracts posted here.

[Blessedat30]

Is hbeag the abbreviation for hepatitis be antigen? If so what does it mean to be negative? Thanks.