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NATAP/EASL: HBV TAF 8 Years in 2 Phase 3 Studies
Natap is reporting many results from EASL 2023. Please read the full report from Natap/Easl. I am just posting the summary:
Patients with chronic HBV treated with TAF only and those who switched from TDF to TAF over 8 years demonstrated:
-High rates of persistent viral suppression (91%-98%)
-High rates of ALT normalization were achieved early and maintained with TAF, while ALT normalization increased in TDF-treated patients switched to TAF in the OL period
-With long-term TAF treatment in HBeAg-positive patients, the rates of HBeAg loss and seroconversion increased progressively(approximately 45% and 30%, respectively)
-In patients with cirrhosis based on Fibro Test at baseline, the majority showed improvement in fibrosis with long-term treatment
-No resistance to TAF was observed.
Treatment with TAF was highly effective in patients with chronic HBV. These results provide support for TAF as the preferred treatment for chronic HBV infection.
Patients with chronic HBV treated with TAF only and those who switched from TDF to TAF over 8 years demonstrated:
-High rates of persistent viral suppression (91%-98%)
-High rates of ALT normalization were achieved early and maintained with TAF, while ALT normalization increased in TDF-treated patients switched to TAF in the OL period
-With long-term TAF treatment in HBeAg-positive patients, the rates of HBeAg loss and seroconversion increased progressively(approximately 45% and 30%, respectively)
-In patients with cirrhosis based on Fibro Test at baseline, the majority showed improvement in fibrosis with long-term treatment
-No resistance to TAF was observed.
Treatment with TAF was highly effective in patients with chronic HBV. These results provide support for TAF as the preferred treatment for chronic HBV infection.
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