HBeAg positive to negative

[bollux]

Hi,

I have Hep B for 16 years now (im now 30 years old), receive it from blood donation... Never mind that now. From 2004-2008 i received Lamivudine therapy and my liver enzymes got down to reasonable limits. They stayed there for 5, 6 years until my last blood control. Here is chronological results;

2008: AST 33, ALT 30, ALP 70, GGT 17, UBIL 10
2010: AST 42, ALT 46, ALP 66, GGT 16, UBIL 11
         HBsAg pos.>250 IU/mL, Anti-HBs neg, Anti-Hbc total positive,
         Anti-HBc IgM neg, HBeAg pos, Anti-HBe pos, HBV-DNA 791 IU/mL
2011: AST 32, ALT 47, ALP 76, GGT 19, UBIL 11
2012: AST 35, ALT 56, ALP 66, GGT 21, UBIL 15
2013: AST 72, ALT 156, ALP 59, GGT 24, UBIL 11
         HBsAg pos.9755 IU/mL, Anti-HBs neg, Anti-Hbc total positive,
         Anti-HBc IgM neg, HBeAg neg, Anti-HBe pos, HBV-DNA 5.45e+7 IU/mL

From what you can see my HBeAg turned from positive to negative and my liver enzymes and HBV-DNA started to raise.....

I'm waiting for specialist check in a few week but want some advices or opinions from any experiences, maybe...

Thank you all in advance..

[fredz2013]

concerned about high ALT & AST...


taking sevibo for 1 yr then i decided to undergo pegintf.
stop taking sevibo for 1 month then started the mono pegintf.

before taking sevibo
HBV Viral load 640M copies/ML

after 1 yr of sevibo
HBV Viral load is 37 iu/ml

before pegintf:
HBsAg II Quantification 1,392 iu/ml
HBV Viral Load 37 iu ml

results- 24 weeks of  Pegintf
HBV Viral load is <6 iu/ml or 35 copies/ml
HBsAg II Quantification 314.90 iu/Ml

I understand the result is good.

what worries me is the consistent  high ALT
and SGOT result is high also (although test done once only after 24wks of pegintf)

ALT 64.60        (declining results)
SGPT 42.11    

i have mild fibrosis result before pegintf .
what will be the effect of consistent high alt in my liver?

[Tom2013]

What were your hbsag and hbv-dna levels in 2004(before start of treatment) and in 2008?Which antiviral are you taking right now? Doctors often suggest taking ursodiol/ursodeoxycholic acid 300mg for a few months so as to keep a check on the rise in the ast/alt levels.My mom's alt/ast levels rose to 100 during hbv treatment.After taking udiliv300 for 1 month those levels have gone down to 42 and 50.Next dosage will start within some days.But it is better to consult a doctor for required amount of dosage before taking such medicines.

[stef2011]

you worsen from wildtype to bcp/precore mutations, while hbeag positive has definitive clearance of hbv on tdf and pegintf hbeag negative has mcuh lower chances.just make the test for mutations but the most useful test is hbsag quant in iu/ml

hbeag is an old view it is not useful anymore to have hbeag neg but only low hbsag quantity on both hbeag pos or hbeag neg

also check fibroscan and possibly start therapy if you have liver damage