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Hbsag quantative test in Europe

Hello,

Since we don't have this test in USA. I'm planing to do it in Italy while visiting Europe next month and I have the following questions:

1) where in Rome I can do the test?
2) how much will it cost me ( hbsag quantity, genotype etc...)
3) do I need an appointment or I can walk in?
4) do they speak English I hope
Best Answer
Avatar universal
the best place to have it is private labs like synlab because in public hospitals it may be difficult to get access

1) where in Rome I can do the test?
there is a very small lab in rome collecting samples and shipping to main sylab laboratory.it is ll ok but not in the rome center, getting there by public transport very messy, you ll have to take a taxi
all public hospitals and many other private labs have hbsag quant but i dont know if you have access

a very good lab i know in civitavecchia (which is 30-45min train from rome) have both hbsag quan and nagalase test available

synlab is everywhere in the north with their own labs,milan is full of their labs, verona, florence, forli, cattolica too

2 hbsag at synlab is about 50€, i dont know for genotype and other tests.email them, they also have ip10 and other research tests available, oxidative stress tests and so on.hbsag in public hospitals is 8€ for italians and free for italian chronic carriers

3 no appointment but you have to explain carefully the type of test because they dont know it at reception (while public hospitals know the test) and confuse that with hbsag qualitative, hbsab quantitative or hbvdna
they have roches elecsys

4 i guess they do, better email them and have appointment so they dont make the wrong test

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Avatar universal
Ok just came back from my appointment with Professor Anna Lok which supposed to be one of the best HBV specialists. Below is a series of my questions and her answers so any please feel free to comment:

1) Dr. Lok what do you think about my results and how you interpret them
HBV DNA 38000 iu, hbsag 224 iu, HBEAG NEG, ALT and AST withing normal range?
   DR Lok: looking at your HBV DNA history it looks like fluctuating between low and little high and in june it was 1100 iu and in august 38000 and that change beleive it or not could be related to time zone difference as there is some research about that change with viral load. We will repeat the tests and see if it come back lower then no treatment and will monitor again after 6 months if it comes high again then interfron for 1 year or possible mix with antiviral and interfron.

2) What is my chances to clear on interfron with such a low hbsag quantity which is 224 iu/ml?
You have to be lucky to clear because usually it is hard because you are HBEAG neg and percentage of cure is much lower. HBSAG quantity considered low if under 100 iu and high if above 1000 iu so at 224 you are low but not so low.

3) What is my chances of getting HCC and is it really 0.5 percent increase every year pass?
Currently and based on the results I have your chances of HCC are less than 1% and your chances getting up if you smoke or use alcohol or being obese but since none of that then your chance is less than 1% for the next 5 years and will increase after age 50.

4) What about the new drugs such as Replicor and ARC525 and will we get a cure anytime soon?
There is several companies working on a cure but that will not make it to market before 5 years from now. However since the competition is complete now with Hepititis C the effort is been shifted to Hepititis B.

5) What do you think of Fibroscan 7.6 result/
Fibroscan result is just one reading and we don't have history of your result plus it is more reliable for hepititis C patients than hepititis B patients because many factors could play into the result.

In summary if your HBV viral load comes up in today's blood test then will recommend treatment with interfron for 1 year. If not high then just watch. The reason why she doesn't recommend treatment because she beleive not much damage in my liver and still young to start treatment.

All the wording above are my own wording and not the exact wording the prefessor said just on the safe side :-)
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Avatar universal
when your hbv population will be killed that will be the best thank you

i really hate this mf virus so much...
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Avatar universal
I must come to Italy to thank you in person if it does really clear :)
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Avatar universal
What does coarsened liver on ultrasound mean compared to 7.6 fibroscan result?

nothing special, US was able to see reflections due to fibrosis, but it has no real values because soemtimes you see that sometimes you dont, US is very bad to see liver damage.anyway 7.6kpa is just close to the borderline when therapy is a must

very lucky hbsag is already on the slow decline, peg should have a very fast result
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Avatar universal
Just got my confirmation on qHBSAG results 2 weeks after making the first ever qHBSAG test.

1st qhbsag (August 17 / 2014) 223.70 iu/ml
2nd qhbsag (August 30 / 2014) 220.80 iu/ml

What does coarsened liver on ultrasound mean compared to 7.6 fibroscan result?

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Avatar universal
Thanks Stef I will keep you posted of what I will end up using and what the professor say
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