Please Assist

[anju440]

Could somebody help what does the below imply on HEPB, is it Normal, Acute or Chronic?

HBsAG - Reactive (18.24) Cut Off Value 0.13 Repeatedly Reactive.....
Anti-HBs - Non-Reactive (<5) Cut off value 8 (U/M)
HAV Igm - Cut off value 0.40
HBc Igm - Cut off value 5.0
HBc Total - Reactive;=or<10
HBeAG - Non-Reactive (0.09) Cut off value 0.18
Anti-Hbe - Non-Reactive (0.80) - reactive is=/<0.40
HCV - Cut off value 1.0

[stef2011]

acute can be considered a benign illness with no fibrosis or relevant liver damage, everything even inflammation regresses in 6-12 months.it clears naturally in 6-12 months and no drugs must be taken because they might interfere with immune system and they will be useless anyway since it clears in 95-98% cases

the difference you make acute/cronic is not very relevant, what matters is the age you get infection, it gets cronic at birth or very young in 95-98% cases.if you have hbsag pos for more than 6-12months or hbcab igm negative it is cronic probably transmitted at birth

in the end most cronic carriers got it at young age, but the most in any case will have inactive virus with healthy lives and no damage only about 5-10% will have hepatitis to become cirrhosis or liver cancer but this takes decades or most of the life since both cirrhosis or liver cancer develop mainly after 40yo.cirrhosis is also a very slow disease there have been centenarios with cirrhosis dyed of other causes than cirrhosis

so in case of cronic hbv you just have to monitor liver damage by fibroscan or biopsy or hbvdna quantity and follow international guidelines that indicate when it is necessary to treat to avoid both cirrhosis/liver cancer

so the answer is:
acute doesn t need cures, it clears in 95-98% cases
cronic doesn t need cures if inactive, when active interferon, tenofovir and entecavir are the cures to stop liver damage and they work in almost 100% cases to stop liver damage and virus replication in combo or monotherapy.
there are plently other old antivirals but must not be used any more because too weak and might make virus mutants

[anju440]

Could you please explain the difference between Cronic and Acute, is any of these curable. Thank you...

[anju440]

Could you please explain the difference between Cronic and Acute, is any of these curable. Thank you...

[stef2011]

HBc Igm - Cut off value 5.0
need to check this result, if negative is cronic and if positive acute

if hbsag present for more than 6 months probably cronic but some acute seroconvert hbsag at one year too