Response to peg 2b + tdf + vit d

[Jatashankar]

Hbsag baseline 6480

After 12 weeks tdf+peg 2b+sim+ntz+artesunate+herbs+vit d
Hbsag 10500

Today's hbsag 8543 after 16 weeks and stopping of all supplements continuing tdf peg and vit d (178ng/ml)

Is the drop related to peg and supplement stoppage or just simple natural fluctuation?
Will continue peg 2b for next 4weeks.

[Aduiski]

If you did all measurement at the same lab then it could be a delayed pegasys effect.
If you used different labs it could be a variation between different lab testing machines/materials.
Hard to know for sure...

[Jatashankar]

today approx after one year of tdf treatment and 6 months ifn meanwhile(stopped), my hbsag has returned back to low levels, lower than baseline(6480iu) ie.4169iu/ml. This is the lowest level of hbsag i met till now. I am on tdf and herbal caps. WHAT DOES THIS LOWERING SIGNIFIES? Is it just a simple fluctuation in immunity or drug induced? What shall be the future expectations?

[flyinsky]

Sorry for you .maybe next time you will clear.i don't know why with such lucky patients works and with others no?!

[twinboys1girl4me]

Sorry it didn't work for you but I give you much credit for trying.  Best wishes for better in the future!

[Jatashankar]

yeah steff right said.. i just gave it a push thinking i might create an odd but no it is'nt that easy. Will continue tdf and retry ifn only in combo if something promising comes in future. Thanx for giving again "the hope"!

[stef2011]

i dont think it is realistic at all to think about hbsag loss in less than 10 years of continuous therapy
only those with low hbsag baseline have good chances, with 6000iu baseline we already knew chances were almost null