in this case i ll consider green coffee blocking vdr not real because vit d does not block vdr it does exaclty the contrary, it is too complex pathways and many other substances for just a dr.
About chlorogenic acid and VDR, I did not find studies, I found some stuff related to the "Marshall Protocol". Here one can better understand: http://synergyhn.wordpress.com/cga/ .
CGA blocks the VDR (as well as Vit D) and makes one feel BETTER. Because it suppresses the immune system. It is the immune system activated that makes us feel sick (like, for ex, when one is on interferon).
There is also bacteria in our gut producing substances that block the VDR, bacteria, viruses as well. This is according to dr Marshall. According to others (maybe vits sellers?), vit D helps. Where is the truth, somwhere in the middle?
You are on vit D?...what is your 1,25D level? ...to see if dr Marshall's theory confirms in your case
I don't think studies should be trusted so much. I took a lot of supps in high doses and did more harm then good, that is why I think it is better NOT to take anything in high doses. and take whole foods if possbile instead of supps, the reason is the way those supps are manufactured, leaving residual stuff, heavy metalls, junk that we swallow with the pill.
But that is only my experience, maybe for others is different.
What I found very good for the liver/health are coffee enemas (I used green coffee). Those were used for cancer therapy (see ****** therapy). I don't think this way CGA and coffeine gets into the blood.
One needs to make sure he got the procedure right before starting, in order not to hurt his colon.
platlets fall is immune system working....it needs platlets in the liver to fix immune system cells there and keep them out of general blood flow
it is a method our body uses to keep the immune system concentrated in the liver
during interferron platelates count falls too much and reason to reduce dosing, is it marker of interferron or immune effect or its just a side effect of no use.
studies are too mixed between antagonist vdr....we should find a very high quality study on coffee and vdr because all human trials give good results on coffee and liver and the glucose lowering effect is also beneficial to the immune system, but the vdr block is not.....
we should find a human study with chlorogenic acid and vdr activation, one thing is certain vdr inhibition is immune suppressive
http://www.marshallprotocol.com/forum39/8252.html
from this discussion and study links, chlorogenic acid is an agonist of vdr receptor, if so green coffee is very ok and make sense with the weak pegintf boost effect