Increasing ALT over the years

[kate0417]

HI There,

Husband is inactive CHB.  ALT has been increasing over the years but in a normal range.  We were at 14 around 10 years ago and today we are at 32 ALT.  AST is stil normal and in the same range 10 years.  I have kept all blood work over the years and the numbers have been slowly increasing.  This year with a cousin unexpectedly pass away with HCC, I am more than ever worry.

Is this something we need to worry about?

Thanks in advance

[StephenCastlecrag]

Management of Hepatitis B has changed dramatically in the last 10 years, not only do we have better drugs such as PegIFN, Tenofovir and Entecavir, we also have better monitoring tools, other than ALT. These days, you should at least test your hbvdna, and a Fibroscan would be most useful too. Also quantitative measure of HBsAg would offer very good indication for truly inactive carrier, it may even be a pointer to a treatment for a cure with PegIFN.

[stef2011]

you need to monitor hbsag quantity in iu/ml, hbvdna pcr, fibroscan to know, alt are useless for this.fibroscan>7kpa, hbsag>1000iu/ml and genotype C are all very risk results.of course hbvdna must be undetectable all time

he better get rid of hbv since there is family history of HCC, check all posts and the members clearing hbv by sequential combo