When VL in the blood goes down,do hbsag quantity usually go down too??

[val_hope]

Hi all,
M just curious,oviously as we know not a lot of drs.order hbsag quantity test or d test is simply no available during treatment,m not sure if mine has been done b4 start of treatment or not coz i wont see my dr again after 3 months time to ask.
Basically i got tested last May n my VL was 37,000,000 iu/ml hery high.I was referd to a specialist.Was prescribed TNF b4 taking d meds VL chech was done which is 101,000 this is my baseline b4 treatment viral load wise but havnt have baseline on hbsag.After a month of TNF my VL gone down to 894.
I know VL doesnt mean much to d extent of d infection thats why m wondering if Hbsag quantity goes down as well with VL going down?

[makeadifferencenow]

Relief to hear you say that Stef Mate!

[stef2011]

no difference between genotypes on response

[makeadifferencenow]

So for geno type C a longer suppression period would be better?

[stef2011]

i dont know if you google you find some studies reporting the sequence A,B,D,C and soemtimes C and D together as the most hard.
some data on genotype E is also coming out.it is also not possible to use hbsag guided response on genotype C because there are not hbsag decline kinetics like for the other genotypes, you may have no decline for 12 or 24 weeks but get response at 48weeks

genotype is not so important in sequential treatment, only years of nucs before peg add on are important in this case

[makeadifferencenow]

What are the response percentages of Peg interferon on Geno Type C?

[mike9111]

That is funy :) I will run the test on my self and let you know. I can't wait until my appointment on the 17th to ask for peginterfron.

[stef2011]

no the hardest is C

very very high.there are no percentages because doctors usually dont treat low hbsag....sounds like they dont want to cure patients and lose a client...

[mike9111]

So stef in my case my viral load is 38000 iu/ml while my hbsag is 223 iu/ml and alt 39 Since I'm genotype D
I've heard that it is the hardest to respond to peginterfron.
What is my percentage and chances to clear on peginterfron alone?

[stef2011]

One more question guys,does it help to have a low VL or having undetected in relation to causing damage to the liver?

of course from hbv no damage when hbvdna is und and alt less than 30, but if you are overweight or eat junk/processed foods the liver can get damaged from that, it is not only hbv to damage

low hbvdna or hbvdna und helps peginterferon response.if hbvdna undetectable naturally you reach about 30% hbsag loss on pegintf, this research was not about asian genotypes it was about A or D

hbvdna und from tdf or etv requires 3-5 years of antivirals to boost peg

[waschool]

you are right, I will update u if I chance on peginterferon.

[val_hope]

One more question guys,does it help to have a low VL or having undetected in relation to causing damage to the liver?

[mike9111]

But waschool if your hbsag is 800 iu/ml that is low so why don't you try peginterfron and you might clear for good. This what I was told here or am'i missing something?

[waschool]

my baseline viral load was 11000 iu/ ml while hbsag was 700iu/ ml. after 6 months of lamivudine viral load was undetected while hbsag increase to 808 iu/ ml. which goes to say there is not much correlation between the two.

[val_hope]

Thanks Stef,so VL going down only an indication that m responding to TNF.I hope my dr.ordered Hbsag quantity as well b4 he prescribed me d meds.

[stef2011]

No, there is no correlation, it may go down or increase with hbvdna undetectable