Aa
Body Weight
Heres my question: i weigh 200 lbs right now...i am thinkn about starting tx again on July 25,next month....if i drop down to 175 how much will this loss of 25 lbs mean in terms of SVR....???...is there a % number to the odds of clearing?...my BMI says i should be 175......i know i got a bit of fat to lose but i cant see 25 lbs of it....
New Study Explains How Pot Kills Cancer Cells
by Steve Kubby, Sierra Times
November 10th, 2003
A new study published in Nature Reviews-Cancer provides an historic and detailed explanation about how THC and natural cannabinoids counteract cancer, but preserve normal cells.
The study by Manuel Guzmán of Madrid Spain found that cannabinoids, the active components of marijuana, inhibit tumor growth in laboratory animals. They do so by modulating key cell-signalling pathways, thereby inducing direct growth arrest and death of tumor cells, as well as by inhibiting the growth of blood vessels that supply the tumor.
The Guzman study is very important according to Dr. Ethan Russo , a neurologist and world authority on medical cannabis: "Cancer occurs because cells become immortalized; they fail to heed normal signals to turn off growth. A normal function of remodelling in the body requires that cells die on cue. This is called apoptosis, or programmed cell death. That process fails to work in tumors. THC promotes its reappearance so that gliomas, leukemias, melanomas and other cell types will in fact heed the signals, stop dividing, and die."
"But, that is not all," explains Dr. Russo: "The other way that tumors grow is by ensuring that they are nourished: they send out signals to promote angiogenesis, the growth of new blood vessels. Cannabinoids turn off these signals as well. It is truly incredible, and elegant."
In other words, this article explains several ways in which cannabinoids might be used to fight cancer, and, as the article says, "Cannabinoids are usually well tolerated, and do not produce the generalized toxic effects of conventional chemotherapies.
Usually, any story that even suggests the possibility of a new treatment for cancer is greeted with headlines about a "cancer cure" - however remote in the future and improbable in fact it might be. But if marijuana is involved, don't expect any coverage from mainstream media, especially since mainstream editors have been quietly killing this story for the past thirty years.
That's right, news about the abilility of pot to shrink tumors first surfaced, way back in 1974. Researchers at the Medical College of Virginia, who had been funded by the National Institutes of Health to find evidence that marijuana damages the immune system, found instead that THC slowed the growth of three kinds of cancer in mice -- lung and breast cancer, and a virus-induced leukemia.
The Washington Post reported on the 1974 study -- in the "Local" section -- on Aug. 18, 1974. Under the headline, "Cancer Curb Is Studied," it read in part: "The active chemical agent in marijuana curbs the growth of three kinds of cancer in mice and may also suppress the immunity reaction that causes rejection of organ transplants, a Medical College of Virginia team has discovered." The researchers "found that THC slowed the growth of lung cancers, breast cancers, and a virus-induced leukemia in laboratory mice, and prolonged their lives by as much as 36 percent."
"News coverage of the Madrid discovery has been virtually nonexistent in this country. The news broke quietly on Feb. 29, 2000 with a story that ran once on the UPI wire about the Nature Medicine article," complained MarijuanaNews.com editor Richard Cowan , who said he was only able to find the article through a link that appeared briefly on the Drudge Report Web page. "The New York Times, The Washington Post, and Los Angeles Times all ignored the story, even though its newsworthiness is indisputable: a benign substance occurring in nature destroys deadly brain tumors," added Cowan.
On March 29, 2001, the San Antonio Current printed a carefully researched, bombshell of a story by Raymond Cushing titled, "POT SHRINKS TUMORS; GOVERNMENT KNEW IN '74." Media coverage since then has been nonexistant, except for a copy of the story on Alternet.
It is hard to believe that the knowledge that cannabis can be used to fight cancer has been suppressed for almost thirty years , yet it seems likely that it will continue to be suppressed. Why?
According to Cowan, the answer is because it is a threat to cannabis prohibition . "If this article and its predecessors from 2000 and 1974 were the only evidence of the suppression of medical cannabis, then one might perhaps be able to rationalize it in some herniated way. However, there really is massive proof that the suppression of medical cannabis represents the greatest failure of the institutions of a free society, medicine, journalism, science, and our fundamental values," Cowan notes.
Millions of people have died horrible deaths and in many cases, familes exhausted their savings on dangerous, toxic and expensive drugs. Now we are just beginning to realize that while marijuana has never killed anyone, marijuana prohibition has killed millions.
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by Steve Kubby, Sierra Times
November 10th, 2003
A new study published in Nature Reviews-Cancer provides an historic and detailed explanation about how THC and natural cannabinoids counteract cancer, but preserve normal cells.
The study by Manuel Guzmán of Madrid Spain found that cannabinoids, the active components of marijuana, inhibit tumor growth in laboratory animals. They do so by modulating key cell-signalling pathways, thereby inducing direct growth arrest and death of tumor cells, as well as by inhibiting the growth of blood vessels that supply the tumor.
The Guzman study is very important according to Dr. Ethan Russo , a neurologist and world authority on medical cannabis: "Cancer occurs because cells become immortalized; they fail to heed normal signals to turn off growth. A normal function of remodelling in the body requires that cells die on cue. This is called apoptosis, or programmed cell death. That process fails to work in tumors. THC promotes its reappearance so that gliomas, leukemias, melanomas and other cell types will in fact heed the signals, stop dividing, and die."
"But, that is not all," explains Dr. Russo: "The other way that tumors grow is by ensuring that they are nourished: they send out signals to promote angiogenesis, the growth of new blood vessels. Cannabinoids turn off these signals as well. It is truly incredible, and elegant."
In other words, this article explains several ways in which cannabinoids might be used to fight cancer, and, as the article says, "Cannabinoids are usually well tolerated, and do not produce the generalized toxic effects of conventional chemotherapies.
Usually, any story that even suggests the possibility of a new treatment for cancer is greeted with headlines about a "cancer cure" - however remote in the future and improbable in fact it might be. But if marijuana is involved, don't expect any coverage from mainstream media, especially since mainstream editors have been quietly killing this story for the past thirty years.
That's right, news about the abilility of pot to shrink tumors first surfaced, way back in 1974. Researchers at the Medical College of Virginia, who had been funded by the National Institutes of Health to find evidence that marijuana damages the immune system, found instead that THC slowed the growth of three kinds of cancer in mice -- lung and breast cancer, and a virus-induced leukemia.
The Washington Post reported on the 1974 study -- in the "Local" section -- on Aug. 18, 1974. Under the headline, "Cancer Curb Is Studied," it read in part: "The active chemical agent in marijuana curbs the growth of three kinds of cancer in mice and may also suppress the immunity reaction that causes rejection of organ transplants, a Medical College of Virginia team has discovered." The researchers "found that THC slowed the growth of lung cancers, breast cancers, and a virus-induced leukemia in laboratory mice, and prolonged their lives by as much as 36 percent."
"News coverage of the Madrid discovery has been virtually nonexistent in this country. The news broke quietly on Feb. 29, 2000 with a story that ran once on the UPI wire about the Nature Medicine article," complained MarijuanaNews.com editor Richard Cowan , who said he was only able to find the article through a link that appeared briefly on the Drudge Report Web page. "The New York Times, The Washington Post, and Los Angeles Times all ignored the story, even though its newsworthiness is indisputable: a benign substance occurring in nature destroys deadly brain tumors," added Cowan.
On March 29, 2001, the San Antonio Current printed a carefully researched, bombshell of a story by Raymond Cushing titled, "POT SHRINKS TUMORS; GOVERNMENT KNEW IN '74." Media coverage since then has been nonexistant, except for a copy of the story on Alternet.
It is hard to believe that the knowledge that cannabis can be used to fight cancer has been suppressed for almost thirty years , yet it seems likely that it will continue to be suppressed. Why?
According to Cowan, the answer is because it is a threat to cannabis prohibition . "If this article and its predecessors from 2000 and 1974 were the only evidence of the suppression of medical cannabis, then one might perhaps be able to rationalize it in some herniated way. However, there really is massive proof that the suppression of medical cannabis represents the greatest failure of the institutions of a free society, medicine, journalism, science, and our fundamental values," Cowan notes.
Millions of people have died horrible deaths and in many cases, familes exhausted their savings on dangerous, toxic and expensive drugs. Now we are just beginning to realize that while marijuana has never killed anyone, marijuana prohibition has killed millions.
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I cant tell a lie....i ate truck loads of those power bars and organic soy ice cream,i blew up too 230 lbs....im now sitting at 205 as i type....i really dont smoke a lot of herb...i use a water pipe and just a pinch like the size of a match head and im ok for all night...3 grams last me for months..and not everynite...i know people who go tru 1/2 ounce a month...i just use it to wake me up...it gives me energy.
come on rocker, tell us the truth why you gained 25 excess lbs.....smoking those doobies gave you the munchies these last few years and you been eating junk foods, lol. I personally would not focus so much on the weight loss but rather on pre-dosing with alaina, riba or interferon, or maybe all of them. This type of thinking will benefit you a lot more then losing weight. Best of luck
Thats just my basic stuff....i also eat tons of apples and raw veggies...my food intake has changed from the above list...basiclly i live on organic whey and blue green algae....yummy.
Yes, I probably could lose 25 pounds in a month if that's what I had to look forward to
rocker ---------- never mind
rocker ---------- never mind
I think that the real question is how you put on 25 pounds to lose!
This is an excerpt from a post of yours almost two years ago. I was always impressed by your knowledge and diligence. I don't claim to have followed your advise, I've kept this just in case the day came that my will power matched my curiosity:
Rocker wrote:
BREAKFAST:greens powder shake...1 tbsp flax seed...i tbsp cummin seed...1 tsp beet powder...1 shot AVC...1 probotic multivitamin...1 glass orange juice...1 gram vitamin c...500 mg NAC...1 tbsp blackstrap molasses...LUNCH:`1/4 pound of alfalfa sprouts...SUPPER:1 organic egg and veggie burger bagel sandwich...25 grams raw almonds...1 tsp flax seed...i tsp cummin seed...1 soya protien shake with carob powder and raw sugar...1 apple...i bananna...1 tbsp raw crushed ginger...10 OCLOCK SNACK:air popped corn lightly sprayed with canola oil and saa salt..........I WOULD EAT MORE BUT BY THEN ITS TIME TO HIT THE SACK......................
Good luck with tx when you start!
% of odds due to weight change?... Let see... were is my atomic calculator...Gee it looks like the nuclear fuel is running low so I can't give you a number but here is so info that might put it in perspective. Remember there are many factors that affect your chances of SVR.
Factors influencing Response to HCV Therapy
Viral Factors
- Genotype (dominant)
- Viral Load (dominant)
- Resistance
Disease Characteristics
- Stage of disease (i.e. Stage 4, cirrhosis)
Therapeutic Schedule
- Doses of PEGIFN & RBV
- Duration
- Adherence
- Early Viral Response
Host Factors
- Race
- Age
- Gender
- Immune Status
- Weight/Metabolic Syndrome
"Retreatment Strategies for Patients Failing First-Line Therapy
Source: Advanced Topics in Hepatitis C Management: Tools for Nurse Practitioners and Physician Assistants"
By: HoChong Gilles, RN, MS, FNP
Obesity
Up to 20% of patients infected with HCV are classified as being obese and have a body mass index (BMI) > 30. Increased body weight has been associated with impaired HCV clearance in the major peginterferon treatment trials. Although multiple reasons are likely responsible for a reduced response to treatment in obese individuals, a key determinant may be the presence of steatosis of the liver, which has been shown to increase hepatic fibrosis and decrease the efficacy of HCV treatment. Steatosis is often found in conjunction with the metabolic syndrome, which is characterized by obesity, hypertension, diabetes, hypertriglyceridemia, and a low high density lipoprotein cholesterol level.
Patients with a BMI > 30 should be considered for HCV therapy, but lifestyle changes, such as diet and exercise, should be prescribed as adjuncts to antiviral therapy, and their implementation before treatment may help patients’ opportunities for response. Decreased hepatic steatosis can be achieved with even modest weight loss (5.9 kg) and has the potential to improve treatment outcomes as well as patient quality of life (Capsule Summary).Pharmacologic weight management with orlistat or sibutramine may be considered for individuals with a BMI > 30 or with a BMI > 27 along with other comorbidities (eg, sleep apnea).
Best of luck with your treatment!
Hector
Factors influencing Response to HCV Therapy
Viral Factors
- Genotype (dominant)
- Viral Load (dominant)
- Resistance
Disease Characteristics
- Stage of disease (i.e. Stage 4, cirrhosis)
Therapeutic Schedule
- Doses of PEGIFN & RBV
- Duration
- Adherence
- Early Viral Response
Host Factors
- Race
- Age
- Gender
- Immune Status
- Weight/Metabolic Syndrome
"Retreatment Strategies for Patients Failing First-Line Therapy
Source: Advanced Topics in Hepatitis C Management: Tools for Nurse Practitioners and Physician Assistants"
By: HoChong Gilles, RN, MS, FNP
Obesity
Up to 20% of patients infected with HCV are classified as being obese and have a body mass index (BMI) > 30. Increased body weight has been associated with impaired HCV clearance in the major peginterferon treatment trials. Although multiple reasons are likely responsible for a reduced response to treatment in obese individuals, a key determinant may be the presence of steatosis of the liver, which has been shown to increase hepatic fibrosis and decrease the efficacy of HCV treatment. Steatosis is often found in conjunction with the metabolic syndrome, which is characterized by obesity, hypertension, diabetes, hypertriglyceridemia, and a low high density lipoprotein cholesterol level.
Patients with a BMI > 30 should be considered for HCV therapy, but lifestyle changes, such as diet and exercise, should be prescribed as adjuncts to antiviral therapy, and their implementation before treatment may help patients’ opportunities for response. Decreased hepatic steatosis can be achieved with even modest weight loss (5.9 kg) and has the potential to improve treatment outcomes as well as patient quality of life (Capsule Summary).Pharmacologic weight management with orlistat or sibutramine may be considered for individuals with a BMI > 30 or with a BMI > 27 along with other comorbidities (eg, sleep apnea).
Best of luck with your treatment!
Hector
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