Clinical trial GS-7977 and BMS-790052

[katla]

I started this clinical trial yesterday, 12 weeks, all oral. (NCT01359644)

There were two arms -  one with and one without Ribavirin. My arm is (unfortunatley) without.

I know some people here are contemplating and/or screening for this trial. I'd love to keep in touch and exchange feedback.

Good health to all...

Kat

[co1251]

Good luck to you too Tanya!  Please let us know if you're a 1a or 1b and if you're tx naive or a null responder to triple therapy so we can keep track of how each type is doing.  Thanks!

[dointime]

"The good news is that if it turns out the 12 wk duration isn't long enough and there's relapse after tx ends, you should be able to re-treat with 7977 in the future because it has such a high barrier to resistance. (Just read they are re-treating the G1 nulls who relapsed after 12 wks 7977 + Riba with 7977 + another DAA and hopefully that will do the trick for them to SVR)"

This sounds great, however as nobody has ever re-treated with 7977 so far it is not yet proven that it will be ok.  So I think that is not something to count on yet.  If it is tested and proven it will be as big a result as finding the combo that works.  After all, who's not going to do the tx if there's nothing to lose from it.  I'd do 3 months and not worry about a relapse if I could just turn around and do 6 months the next time.    

Great input co1251, thanks.
dointime

      

[co1251]

Anytime, dointime!

[katla]

Jimeeboy- today was day 2. And good luck with the biopsy.

UKgirl- Yesterday I was there for 8 hrs.; blood tests every couple of hours.

co1251- I think you're right. The clinicaltrials.gov site listed gt 1,2 3.

Tanya- good luck...so glad you'll be around to compare notes with.

dointime- I agree with you. The trial doctor reluctantly admitted that not only is the possibility of ever retreating with 7977 an unknown, the possibility of becoming resistant to ANY type of future treatment is unknown...hence all my anxiety.

Well, I am relieved to have found some brothers/sisters in arms....

[UKgirl55]

The resistance factor is an unknown, but the fact that they are going to re-treat the nulls that relapsed says a lot about what they must already know.

[Jimeeboy]

Thanks.

Good luck to you.  Day 3 tomorrow. Short visit....lol