Current quest trial SF

[1swimmer]

Hi there,
I have a friend doing a trial for quest/AbVie in San Francisco and was curious if anyone else was doing this.
I am not that familiar with the new drugs as I did the protease boceprevir. I achieved SVR in April 2013.
I think his trial is also part of a long term study.
Thanx,
C

[hepcandme]

OK

Got it

Good luck on your upcoming treatment!

I think this one is going to do it for you, Hector,  and you can just cheer us on from the sidelines with your HepCfree new liver!

~Linda

[HectorSF]

First trial..."you must have already participated in an Abbott sponsored trial? "
Yes that's right. For the second trial also.
The second study is ONLY for people that have already competed a trial using these AbbVie or Abbott drugs. They are looking to see if people using these drugs have developed drug resistance.
"A follow-up study to assess resistance and durability of response to three experimental drugs ABT-450/r, ABT-267, and ABT-333 in subjects who have participated in Phase 2 or 3 clinical studies with these agents for the treatment of chronic hepatitis C."

So none of these trial would be relevant to you having cirrhosis pretransplant.
The first 2 trials are only open to AbbVie or Abbott previous trial patients
The 3rd trial "A Study to Evaluate Chronic Hepatitis C Infection in Adult Liver Transplant Recipients "... those more than 1 year post transplant with recurrent hepatitis C.

Make senses?

Hector

[HectorSF]

Since I have already done Sovaldi + ribavirin for 48 weeks this is the only option available right now for me that I haven't already done.

I will be doing 12 weeks of Sovaldi, Olysio + ribavirin just like everyone else starting August 28th.

I was just talking to my PA today who will be overseeing my treatment. If I fail this treatment we have already talked about the future better treatments that will be available if I relapse. Plus by then we will have more study data from other posttransplant treatment studies to see what works best for someone like myself.

NOTE: This Sovaldi combined with Olysio has never been studied us post transplant folks.

Hector

[hepcandme]

So, in order to be in the first trial you mentioned, Hector, you must have already participated in an Abbott sponsored trial?

And the second trial, is that open to cirrhotics? I have visited their website and am still confused about who is eligible

[Rangle]

How long is your treatment  for hector?

Good luck

[1swimmer]

Hi there and thanx for the response.

* A Study to Evaluate Long-term Outcomes Following Treatment With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection

I'm pretty sure this must be the one. He doesn't mind the 4 hour drive to the city as his copays to treat using his insurance were out of reach. He is taking the ribavirin. I want to relay anything useful I hear on this forum as he is unlikely to view these pages.

Good luck Hector. I saw that you are finishing your tx for TB soon. Your time to kick the hepc virus for good is coming.
Cheers,
C

[HectorSF]

There are a number of AbbVie trials ongoing and currently recruiting here is San Francisco.  Here are two that are recruiting.

* A Follow up Study Designed to Obtain Long Term Data on Subjects Who Either Achieved a Sustained Virologic Response or or Did Not Achieve a Sustained Virologic Response in an Abbott Sponsored Hepatitis C Study

Condition: Hepatitis C
Interventions: Drug: ABT-450/ritonavir;   Drug: ABT-333;   Drug: ABT-267

* A Study to Evaluate Long-term Outcomes Following Treatment With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection

Condition: Chronic Hepatitis C Virus (HCV) Infection Genotype 1
Interventions: Drug: ABT-450/r/ABT-267;   Drug: ABT-333;   Drug: Ribavirin (RBV)
---------------------------------------------------------------------------------------------------
There is also a trial at the UCSF liver transplant center for us post liver transplant folks.  It requires a candidate to have recurrent hep C and be at least one year post transplant, otherwise I would have done this trial. Will do Sovaldi, Olysio + Ribavirin instead.

* A Study to Evaluate Chronic Hepatitis C Infection in Adult Liver Transplant Recipients
Open-label, Phase 2 Study to Evaluate the Safety and Efficacy of the Combination of ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adult Liver Transplant Recipients With Genotype 1 Hepatitis C Virus (HCV) Infection
They will study the outcome of 24 weeks of treatment with and without ribavirin. They is drug to drug interaction of this treatment with the transplant immunosuppressant (tacrolimus/cyclosporine) which will need to be adjusted, but SVR rates from a previous study was very high.

Cheers!
Hector