Doingtime

[Roberttherock]

I have failed treatment with Incevik.  I was undetectable at 4 wk, 12wk and post tx (24 wks).  I relapsed at 6mo.  I was told I could not retreat with Incevik.  I was forced to only stay on the drug for 24 wks because of my success.  Is it an option to try victrelis?

[Willy50]

After 24 weeks of taking a PI you have resistant virii strains.  Another protease inhibitor (such as victrelis) will work no better, and in all likelihood will not work as well.  It will take about 2+ years for your resistant viral strains to revert back to "wild type", at which time you might either try another protease inhibitor or one in combination with other DAA's.

The short answers is no, retreating with another PI is not a useful option in the near future.

willy

[hrsepwrguy]

They are the same type of drug (NS3/4A protease inhibitor) so resistance will most likely be an issue

There are no clinical data on re-treating patients who have failed an HCV NS3/4A protease inhibitor-based treatment, nor are there data on repeated courses of INCIVEK [see Microbiology (12.4)].

http://pi.vrtx.com/files/uspi_telaprevir.pdf

VICTRELIS efficacy has not been studied in patients who have previously failed therapy with a treatment regimen that includes VICTRELIS or other HCV NS3/4A protease inhibitors.

http://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.pdf

[can-do-man]

No not an option as you would have the same results. you need something that does not include interferon... Plenty of time for you guy just hang in there.