Failed triple tx with Incivek

[Advocate1955]

My husband failed triple tx with Incivek and is stopping treatment today (4/11/12).

He is:
age 59, Hispanic, G1a, has probably had Hep C for 30+ years
diagnosed in 2007
f1/f2 per liver biopsy in 2007
partial responder to first therapy (SOC in 2007) - had < 2 log drop
f4 per liver biopsy in 2010
partial responder to Consensus Interferon-daily Infergen injections/1400 mg Riba) in 2010, had < 2 log drop
started triple tx with Inc on 9/30/12:  VL's were: week 4 = 78, week 8 = UND, week 12 = UND, week 16-ish = DET<12, week 20-ish = DET<12, week 24-ish = DET 22
All VL tests were done with the Abbott Real Time PCR Assay (Limit of Detection (LOD) 12 IU/mL, Limit of Quantitation (LOQ) 12 IU/mL

Advocate1955

[screaming48]

I am so sorry, you guys have tried so hard. Hopefully something new will come along soon. Keeping you both in my prayers..

[3xlucky]

What terrible news to endure.  To think you are clear and then have it come back.  I know three weeks ago I discussed future options with my trial team as after 5 months I am still not undetected
On the Gilead clinical trial and wanted to know what my options might be if I failed.  They were very excited about the new oral trials and that they thought a lot of drug companies were in competition to work with drugs like the new phamasset one that Gilead bought and people that failed a protese inhibitor would be sought out to prove their treatment would work for them. They were very optimistic that it would not be long for better treatments to come up.  I am still in the running but not that optimistic this trial will work for me.

[Advocate1955]

To all, thanks again for your kind words of support.  I checked clinicaltrials.gov again last night to see if there are any trials recruiting in our area that my husband might be eligible for after the wash out period, but I didn't see any.  Let me know if you hear of any specific ones that you think I should research for G1a, Cirrhotic, and previously treated.
I truly appreciate everyone reaching out to us.
Advocate1955

[jsf52]

I am so sorry to hear that this did not work for your husband.  I have treated twice in the last year and both times tx failed me (the first was SOC and did not have a 2 log drop at 12 week mark and the other was a clinical trial and my VL went up at the 8 and 10 week marks so they stopped me after shot 12).  I am now in a resistance study to try and figure out why us Geno 1a's have such a struggle with resistance.  The trial doctor firmly believes that there will be a non interferon cure for us within the next 2 to 4 years.  Keep faith - will keep you and your husband in prayers.

[bbj2856]

When I red this it is like we all know each other he has faught so hard so long endured so much. I am going continue to pray for him and u  becase u are a support anchor for him. I pray there is new meds or something to help him and he can continue on with his life . You are such a support here so very knowalage to us all. God Bless and  never give up . God bless you and hold him close in his healing hands
bbj2856

[Bovary73]

Often when I read your posts I was so touched by the fact that you engage in this tx so much on behalf of your husband. It really touched my heart and I really think you husband is a very fortunate man to have a wife as you, being so supportive and educating yourself so much in this.
I'm so really sorry to hear that it didn't work for your husband this time, but I pray, like many others here, that in the near future, there will be other types of treatment with less sx's and more SVR's.
I hope your husband's liver had some benefits from this treatment, even if the virus isn't gone.

Wish you all the best..