No, those are antihistamines and won't damage the liver. There are a couple of websites that show drug label info, like rxlist.com and drugs.com. I comb through those if I am considering using something new, looking for any liver side effects of drugs. There are 2 liver enzymes, AST and ALT. ALT is made in the liver and it's leakage into the bloodstream indicates cell damage to the liver. AST, however, can also come from damaged muscle and heart. Some people can show higher AST after a strenuous workout at the gym.