Telaprivir works

[lab-rat]

I haven't posted in a very long time but I just wanted to share news with those of you who may be following the trial drugs  

I just received my 48-week post treatment test results and I'm negative !!!!!!!!!

I was in the control group (placebo) of the Prove 1 trial for vx-950 and treated for 48 weeks with standard treatment.  I responded well in the beginning but 11 weeks post treatment I relapsed.  So I joined a roll-over trial and treated for a total of 24 weeks - the first 12 with telaprivir - the real thing not the placebo.   I went negative at week 1 and remained that way until the end...and now.  Just wanted to let everyone know that Telaprivir works!

[thegypsy9164]

Wow you guys,

It is midnight here and I am having one of my can't sleep nights.  I've been sitting and laying here just looking at my 2 1/2 year old baby girl thinking about what a blessing from God that she is.  I just wanted to thank you all for your hopeful input on the vertex and bocepravir trials.  I'll do shot 22 tomorrow.  My hemo is back down at 8.7 and I've felt pretty sh- - tty.  Nurse called today to say to reduce riba to 600.  I argued for giving me some blood so I can keep up a more therapeutic riba dose since such a reduction scares me that virus could come back with a only a half daily dose.  Missed a day of work this week (unpaid) but hanging in there.  Sleep tight, don't let the side effects bite.
Joey

[lab-rat]

Hey mremeet - good to hear from you!  UR right about fading into post-svr land - it's all becoming a distant memory.  Actually I didn't really know at week 24 - but I certainly did hope.  Take care of yourself and have a great life!!

[mremeet]

Hey there labrat, great news! Congrats, but I guess we knew by 24 weeks post UND you would make it. Anyway, we probably won't be speaking to one another again. I'm fading off into post SVR-land, sounds like you are too. It's been a long strange trip. Hope you enjoy the rest of your hep c free life, I know I sure will.  Best regards and best of luck to you - meet

[annieCinMD]

Since I started the PI at week 16, due to waiting on results, and because I think my study coordinator forgot to bring me in earlier, probably week 14, 12 weeks of the PI will put me at 28 weeks. So, I think I am already rolled over. I agree that I will know how it's going pretty soon (next week). She just sent me an email telling me my neutrophils are low, and to cut back on my Peg on Friday. Have to look up what that causes because I was miserable over the weekend and still don't feel very good.

[newleaf09]

Will the trial allow you to roll-over at 24 weeks?  That was the boceprevir protocol for people who still were detectable at 24 wks.  Lab-rat had a good experience.  I think you will know how it's going to go within a month of starting the teleprevir, just by the PCR.  You would still be on only 48 wks of TX and it may make all the misery up to this point worthwhile.

[annieCinMD]

Yes, I thought I would give the PI a chance. I will get my first results next week. I'm curious as I'm sure they are, too, if it works being introduced part way in. It is pretty obvious that they work pretty well if started at offset. If it comes back UND, I will definitely try to stick out the duration. They used week 4 and 12 as critical points, just as in SOC. I think I will be offered out if I show up UND by week 4. I am honestly hoping for UND at week 2. After that conversation with my friend it turns out she still was UND at 6 months. I don't think that had the stats they do now about clearing by week 12 or off. I'm just glad it bought her as many years as it did. I'm pretty sure the VL tests weren't as accurate as they are now, either. As I only get 12 weeks of the PI, and I think the majority of my problems stem from the Peg and Riba, I want those 2 out of my system. If it works, it works. I know to expect the worst at this point.