Telaprivir works

[lab-rat]

I haven't posted in a very long time but I just wanted to share news with those of you who may be following the trial drugs  

I just received my 48-week post treatment test results and I'm negative !!!!!!!!!

I was in the control group (placebo) of the Prove 1 trial for vx-950 and treated for 48 weeks with standard treatment.  I responded well in the beginning but 11 weeks post treatment I relapsed.  So I joined a roll-over trial and treated for a total of 24 weeks - the first 12 with telaprivir - the real thing not the placebo.   I went negative at week 1 and remained that way until the end...and now.  Just wanted to let everyone know that Telaprivir works!

[copyman]

are you going to do 12 weeks of the PI ? Not sure if that would be enough TX. what concerns me is you still being detectable at 16 wks. You may want to look into this before you make that decision. Since you are a stage 1 you might be better off waiting a few years for the new drugs to come and doing 24 weeks then. The PI data out for non-responders & relapsers is really good, over 70%.
Best of luck

[annieCinMD]

I going into your camp with newleaf. After the most miserable weekend I've had in a long time, I've made a decision to go off at week 28 at most no matter what. 10 more weeks. I just crossed over to the PI arm of the Sch 900518 trial, after so-so results on SOC. Still not UND at week 16. I'm willing to give the PI the full run, but the sides from SOC are too much for me. I, too am concerned about sides that will never go away, and permanent damage. I talked to my friend that I speak of frequently earlier tonight. She found out a couple weeks ago that the virus returned, after many years of remission. She hasn't called her liver doc yet, but said she needs to deal with it. She told me I should quit the meds. It messed up her  eyesight and it never came back. I'm Grade 1 Stage 1 as of Jan '07, so I have time, and was always healthy.  My mother thinks I should quit, too. As a single parent I have to work, and I start Grad school in the fall. Quitting at week 28 will give me a few weeks to start feeling better before classes start in September.

[Magnum]

Wonderful, wonderful news! As a 4-time non-responder, this is building my hopes sky high for next year... good for you!

Magnum

[lab-rat]

Thanks for the kind words everyone!

isobella - How do you know you're in the placebo arm?  Aren't you blinded in your study?  I know when I was in the control group I pretty much guessed it right away - but I always held out hope that I was getting the real thing.

copyman - obviously they're still trying to tweak the treatment times to come up with the optimal...I feel I got lucky.  I'm betting that 33 weeks is sufficient since you went und at week 3.  Best of luck to you!

zazaa - congratulations!!! We made it!!! - I'm so happy for you.

lapis - good luck with your 12 week pcr next month - that was one I  really sweated over since that's where I relapsed the first time.

nanaviking - I'm genotype 1a.

Good luck to all of you.  This forum has been a great resource in helping me get through.  Thanks!

[copyman]

all the new drugs close to approval are targeted to genotype 1's

[nanaviking]

Hi,
  I was just wondering what Geno type you had before starting the Telaprevir.    I am 1a and have been resistant to traditional treatment due to the high risks of long term negative effects with a low rate of sucess with genotype 1a.  I'm hoping for a treatment with a better sucess rate and lower risks. Thanks