Trying to figure this out.

[Diane12855]

After being on tx for almost 12 weeks, I am seeing a huge variation of sx from week to week and wondering if it has anything to do with where I give myself the shot. I take my shot of Friday evening at about 6:00, and usually feel OK till Sat. evening, then things get worse till Monday and level out for Tuesday and maybe Wednesday. Some weeks I feel pretty good on Thursday and Friday, but some weeks I feel horrible those days. I notice the fat in the center of my stomach seems to be a different consistency than the fat more to the side, and I'm wondering if that causes it to take longer to get into my blood stream.

Anybody else notice a difference?

[nygirl7]

Jez Trin we're talking about 72 weeks and then look at Michael........"the first two years of treatment" "harder than the last 73 weeks"....! What whiners we sound like huh?!!!!  Still I think the Intron was horrible yet can't even imagine doing Infergen for 72 like DebC did.  It makes me realize what a big baby I was about the whole thing.  Or a Beagle Bailey with that serious hemo crap - man oh man how did he handle that?  Yes Michael you put it right into perspective for real!

I 'thought' the first few months were difficult (especially right after the hemo nightmare) until after week 48 when I thought I was going to go out of my mind believing it was never going to end and being so tired of all the contiuous new / never ending problems.  But it worked and that is what matters in the end. If people hadn't told me to suck it up and just not focus on that stuff I might not have.  Best advice I ever took!

We made it.........somehow............we are some tough cookies ;)

[mikesimon]

For me the fist two years of TX were a lot harder than the last 73 weeks. I attribute that solely to the switch in Pegs from Peg-Intron, which practically killed me, to Pegasys which made those last 73 weeks so much easier.

Mike

[Trinity4]

That extra 6 months was a whack in the head hey?

[portann]

I never thought about that!

I rotated among four areas, thighs and stomach sides, with fat content on thighs higher than tummy.  I don't recall whether thigh days delayed my reaction or not. :)

Knowing roughly when you'll be hardest hit during the week is so important for you, I know, because you do a lot of running around at work. I didn't have that kind of pressure, so one day just slipped into the next and it didn't impact my job (what job?).

And you have a position that demands alertness that is so costly if you goof. :(

As my hemoglobin dropped and dropped and dropped, I found it hard to stay on my feet for long. And harder to think straight, whether my days were  'good' or bad.

The thing I remember most about feeling crummy was that as soon as I'd figured out how to handle what one day or one week had dished out, the crumminess would morph into something different and leave me scrambling to fix the next set. There was no point hanging on to old strategies because they stopped working.

Whether the fat delays your reaction or not, side effects suck BUT (and I'll bet you) one day, you'll barely remember them. (My dil just had the worst labor without any meds and five days later, almost all the 'bad' is forgotten.)

Here's something about serum peaking (window of 72 to 96 hours) and 'worst days'. I seemed to feel crummy within the first 48 hours, anyway, which didn't fit the conversation about the 72 to 96 hour window:

http://www.medhelp.org/posts/Hepatitis-C/Worst-day-poll/show/722721

Twelve-weeker test coming up, I know, I know.....fingers and toes crossed...

xoxo

Susan

[nygirl7]

If fat had anything to do with it by week 20 I would have had no sides at all cause I had no more fat (or vice versa). It followed me all the way through week 72 and past as well and some were extremely drastic sides.  They come, they go, they come, they go, they change, they come back.......not the naseau or lethargy but the autoimmunes and the hemos - living hell.  But being cured, it seems ridiculous to have complained after watching people with worse ones than I who did not succeed.

Aren't your numbers still quite strong for getting so far into tx - I thought you had avoided the anemia and stuff very well so far?

[EyesofBlue55]

Hope that you are gonna have a good week this week!