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Resistance to Peg and Riba
Is there any info out there about resistance to Peg and Riba?
I am a previous non responder with the opportunity to treat with double Riba. If this fails, would my virus then be immune to Peg and Riba next year and therefore reduce my chances of clearance when Teleprevir becomes available.
I am a previous non responder with the opportunity to treat with double Riba. If this fails, would my virus then be immune to Peg and Riba next year and therefore reduce my chances of clearance when Teleprevir becomes available.
Scientists don't know currently why some people's immune systems do the job and others don't. There are so many factors including genetics, chemistry, diet and who knows how many other minute factors that determine success that they don't understand.
I suppose they are learning something though since apparently they are developing a test that can determine if a person will have success with tx.
I suppose they are learning something though since apparently they are developing a test that can determine if a person will have success with tx.
Do what. If our immune system is what does the job, then I would think you would want to carefully build up your immunity as much as possible.
Long term resistance isn't an issue, gotcha.
Long term resistance isn't an issue, gotcha.
Cory, long term resistance isn’t an issue with interferon; the virus rapidly returns to its wild-type condition after completion of therapy. Of course, I haven’t heard from a real, live hepatitis c specialist, so what do I know?
I have also spoken extensively about this with a renowned hepatologist Cory. Interferon does not attack the virus, it ramps up our immune system to do the job. With null responders the interferon does not effectively interact with the immune system to boost it enough to do the job. With relapsers it does do the job and UND occurs but once the interferon is stopped the virus has not been suppressed effectively enough to attain a sustained virological response. It's how the body's immune system interacts with the interferon, not because we develop a resistance to it. Changing pegs works for some or using consensus interferon. They are still all interferon but with a different molecular structure.
BTW, did you read the link I provided?
Trinity
Many people have treated mulitiple times with SOC and finally reached SVR. This could not happenend if resistance to interferon occurs.
Trinity
BTW, did you read the link I provided?
Trinity
Many people have treated mulitiple times with SOC and finally reached SVR. This could not happenend if resistance to interferon occurs.
Trinity
I have a question. What do you mean drug resistance DOES NOT develp with interferon & ribavirn ? Can you elaborate ?
I heard from a real , live hepatitis c specialist , that Resistance to PegIFN is in fact, real, and is certainly possible, which is why i believe this.
I heard from a real , live hepatitis c specialist , that Resistance to PegIFN is in fact, real, and is certainly possible, which is why i believe this.
Drug resistance DOES NOT develop with interferon and ribavirin since these drugs do not specifically target the enzymes of the virus used in the viral replication process.
http://www.hcvadvocate.org/hepatitis/Basics/New%20Antivirals_09.pdf
Trinity
http://www.hcvadvocate.org/hepatitis/Basics/New%20Antivirals_09.pdf
Trinity
It is entirely possible to develop a resistance to IntFN. This is something you need to discuss with your Doctor. During tx if you continue to take PegINF & Riba and your VL does not fluculate this could largely be due to being resistant to Interferon. This is completley different than Insulin Resistance, so try not to get the two confused. Do you know why you are a non-responder burned74? Have you been tested for Insulin Resistance?
I don't think your math works out for non responders. if 100% of non responders failed the first time, and fifty percent of them succeed with the new PIs then your chance with a pi added is 50% greater.
You are not comparing apples to apples. You would have to compare the success rate of non responders only to soc when they retreat to nonresponders with a PI added. The fifty percent success rate with soc is for treatment naive geno 1a and 1b.
At the same time you are trying something different with double riba, you were at 2/2 6 years ago, and maybe this is the way to go. Hopefully bill1954 will add his comments. Are you going to treat for 72-96 months?
It will not add to resistance if you treat, but by the time you are finished treating telaprevir will very likely be on the market. Also since you are a non-responder. I think a good doctor could convince your insurance to pay for a new drug rather then spend the money on something that failed previously.
Good luck - Dave
- Dave
You are not comparing apples to apples. You would have to compare the success rate of non responders only to soc when they retreat to nonresponders with a PI added. The fifty percent success rate with soc is for treatment naive geno 1a and 1b.
At the same time you are trying something different with double riba, you were at 2/2 6 years ago, and maybe this is the way to go. Hopefully bill1954 will add his comments. Are you going to treat for 72-96 months?
It will not add to resistance if you treat, but by the time you are finished treating telaprevir will very likely be on the market. Also since you are a non-responder. I think a good doctor could convince your insurance to pay for a new drug rather then spend the money on something that failed previously.
Good luck - Dave
- Dave
Great question, Portann.
I was all set to continue waiting for a year or so for the STAT-Cs but then I researched a little further.
The info I have seen is that previous non responders have about a 50 per cent chance of SVR with the StatC PIs (as opposed to relapsers and those who are treatment naive, whose chances of SVR are over 80 per cent)
This 50 per cent cure rate is not that much different from the chance I had in 2004 when I first treated, when I had a VL reduction of close to 2 log but not quite.
I figured if this doesn't work, I can always retreat in a year or so when the new drugs come out. I was a 2/2 in 2004. Maybe I am a 3 now but I don’t know for sure. Before starting this trial I do get a Fibroscan so I will know exactly where my liver is.
I was all set to continue waiting for a year or so for the STAT-Cs but then I researched a little further.
The info I have seen is that previous non responders have about a 50 per cent chance of SVR with the StatC PIs (as opposed to relapsers and those who are treatment naive, whose chances of SVR are over 80 per cent)
This 50 per cent cure rate is not that much different from the chance I had in 2004 when I first treated, when I had a VL reduction of close to 2 log but not quite.
I figured if this doesn't work, I can always retreat in a year or so when the new drugs come out. I was a 2/2 in 2004. Maybe I am a 3 now but I don’t know for sure. Before starting this trial I do get a Fibroscan so I will know exactly where my liver is.
Hi there,
The question that pops into my mind is why you're considering treating at this time instead of waiting for the STAT-C's to be added to Peg and Riba. Waiting would be my first choice, barring advanced fibrosis.
What do you mean by 'previous non-responder'?
The question that pops into my mind is why you're considering treating at this time instead of waiting for the STAT-C's to be added to Peg and Riba. Waiting would be my first choice, barring advanced fibrosis.
What do you mean by 'previous non-responder'?
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