Aa
has anyone been on the trial study for TMC 435?
Has anyone participated in the trial study for TMC 435?
Sorry, I have to post again, I'm out of practice.
Magnum, as Spectda indicated, TMC435 has as good or better results as Tela and Boc, but a better side effects profile. So no more anemia than with just the riba, and no Tela rash. That's the advantage! And a big one it is. Some people think the side effects are less because TMC435 is dosed in a much lower amount than Tela or Boc.
Also, of course I meant to write my husband achieved SVR with a 24 week treatment. He cleared in 4 weeks or less (we're still not unblinded.) It was truly a pretty decent ride for him. Best of luck to any of you treating with TMC435, and to everyone else as well.
Magnum, as Spectda indicated, TMC435 has as good or better results as Tela and Boc, but a better side effects profile. So no more anemia than with just the riba, and no Tela rash. That's the advantage! And a big one it is. Some people think the side effects are less because TMC435 is dosed in a much lower amount than Tela or Boc.
Also, of course I meant to write my husband achieved SVR with a 24 week treatment. He cleared in 4 weeks or less (we're still not unblinded.) It was truly a pretty decent ride for him. Best of luck to any of you treating with TMC435, and to everyone else as well.
Hi there,
My husband was in the Phase IIb trial of TMC435. He received the real stuff and cleared in 24 weeks. He had only mild to moderate side effects. It seemed to us there was not a rash or more anemia associated with TMC435 as with Tela and Boc respectively, he only had to take it once a day, and it seems as effective as those drugs. We're fans.
If you have any specific questions I'll try my best to answer.
My husband was in the Phase IIb trial of TMC435. He received the real stuff and cleared in 24 weeks. He had only mild to moderate side effects. It seemed to us there was not a rash or more anemia associated with TMC435 as with Tela and Boc respectively, he only had to take it once a day, and it seems as effective as those drugs. We're fans.
If you have any specific questions I'll try my best to answer.
According to the phase III trials, it's still a triple therapy with Riba/Interferon. So the side effects torture is still there with the possible exception that TMC 435 has a better response rate than Tela or Boce. That's what I read into this...
http://www.clinicaltrials.gov/ct2/show/NCT01290679?term=TMC435&rank=19
Magnum
http://www.clinicaltrials.gov/ct2/show/NCT01290679?term=TMC435&rank=19
Magnum
Tele has the horrendous rash, Boce has the Anemia (which I haven't had a problem with in the last 4 treatment attempts). I have a battle going on with my own thinking about all this now. That is, should I gamble and wait for the non Riba/Interferon treatment coming out in the future or treat again now? Decisions, decisions, decisions...
Magnum
Magnum
The results look very promising to me.
Telaprevir and Boceprevir both have issues with tolerability as would be expected in first generation DAAs. Improved or similar efficacy and "no statistically relevant difference in safety and tolerability between the TMC435 and placebo treated groups. " is a development that shouldn't be underestimated. After all, look at the discussions people are having about boce and tela and which side effects they will risk when determining what to treat with.
In addition to efficacy and tolerance to the drug, the difference in one's ability to be compliant with a once daily dose rather then 2-3 times a day is quite significant in my opinion. Vertex would not be investing in a trial to study the comparison of dosing telaprevir 3 times a day to dosing 2 times a day if it wasn't
Welcome to the forum Liz,
-Dave
Telaprevir and Boceprevir both have issues with tolerability as would be expected in first generation DAAs. Improved or similar efficacy and "no statistically relevant difference in safety and tolerability between the TMC435 and placebo treated groups. " is a development that shouldn't be underestimated. After all, look at the discussions people are having about boce and tela and which side effects they will risk when determining what to treat with.
In addition to efficacy and tolerance to the drug, the difference in one's ability to be compliant with a once daily dose rather then 2-3 times a day is quite significant in my opinion. Vertex would not be investing in a trial to study the comparison of dosing telaprevir 3 times a day to dosing 2 times a day if it wasn't
Welcome to the forum Liz,
-Dave
Just wondering why you picked Boceprevir. I'm starting in June, decided on Telaprevir but doc had recommended Boceeparevir. Just wondering what tipped you to Boc
pcds
pcds
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