Syndrome of Gilbert diagnosis

[maqroll]

Good afternoon, I'm a male , 3 years old.I've just taken my latest blood tests and I have found an high level of unconjugated bilirubin, 2,85 mg/dl instead of 0-0,8 mg/dl. the conjugated birilubin is 0,36 mg/dl instead of 0-0,2 mg/dl. All the other results are normal, including: AST: 25 U/l (range 15-37) ALT 28 U/l (range 12-78) GGT 14 U/l (range 15-85), hemoglobyne and erithrocitus. My health condition is currently good, the color of my urine and stool is normal, I'm not loosing weight, I don't feel itch. My eyes are a kind of slightly yellow. My doctor diagnosed a Gilbert Syndrome: any comments, suggestions? thanks regards

[maqroll]

Hi Hector, I'm 39 years old.
The doctor who is following me is a gastroenterologist, basically he told that can't be hepatitis since my transaminase values are perfect and it can't be anemia since my hemoglobina and erithrocitus are good. Actually, he told that if less than 20% of total birilubin is conjugated and if there's a huge raise of unconjugated birilubin with thah kind of blood test must be Gilbert's syndrome. I'm scared to have a kind of obstructive jaundice, but again he told in that case conjugated birilubin would be huge and more than 50% of the total and GGT and transaminase would be much higher than normal. does anyone want to share his opinion with me? thanks regards

[HectorSF]

How old are you?

What is your Total Billirubin number? 3.21 ?
2.85 is 88% of 3.21 so I am not sure Gilbert's is the answer. But I am not a doctor either.

You may want to see a gastroenterologist (if this doctor isn't one) for a second opinion just to be sure of your diagnosis and confirm you have nothing to worry about.

What other blood test were done?
Have you been tested for hepatitis B & C?


Normally, 90% or more of measured serum bilirubin is unconjugated (indirect-reacting). When the total bilirubin level is elevated and fractionation shows that the major portion (≥90%) is unconjugated, liver disease is NEVER the explanation. Instead, the clinical suspicion should turn to one of two explanations. If the patient is young and healthy, an inherited decrease in the inability to conjugate bilirubin is likely; it is referred to as GILBERT'S SYNDROME. It causes no symptoms and is associated with no liver disease. Interestingly, fasting and intercurrent illnesses such as influenza often make the level of unconjugated bilirubin even higher in those with Gilbert's syndrome. This syndrome is easily diagnosed when all the standard liver test results are normal, and 90% or more of the total bilirubin is unconjugated. There is no need for an imaging study or liver biopsy in cases of suspected Gilbert's syndrome.

Elevations of the unconjugated bilirubin level, when the conjugated bilirubin level remains normal, may also indicate an increased load of bilirubin caused by hemolysis. Anemia and an elevated reticulocyte count are usually present in such cases.

Good luck!
Hector