Hi and welcome,
Structural spinal conditions could definitely explain what you've mentioned...
"Lumbar spinal stenosis occurs when a nerve root in the lower back is compressed. A person may experience tingling, weakness, or numbness that radiates from the low back into the buttocks, thighs, or groin. These symptoms are often referred to as sciatica, which describe symptoms that travel along the sciatic nerve in the back of the leg.
Cervical spinal stenosis occurs when a nerve root in the neck is compressed. A person may experience tingling, weakness, or numbness that radiates to the arm or hand." https://www.arthritis-health.com/types/osteoarthritis/spinal-osteoarthritis-symptoms
Incidental findings on brain MRI in the general population are common, with out specifying what the 'changes of uncertain significance' actually is you'd only be guessing....the most common type of lesions are vascular related and typically micro (1-3mm) but there are other possible changes besides lesions the radiologist might be meaning so you're honestly better off being patient a little while longer and trying not to work this unknown out and potentially worrying about something that may turn out to be nothing at all like your thinking....
Hope that helps.....JJ