Well, it's an old term, but none of the doctors could pronounce it and the transcriptionists couldn't speel it. So they use "age-related" now.
Yes, I saw that. The site notes that PVL at least usually involves coginitive impairment, and thank God that one hasn't happened yet.
ess
Ess, that page describes periventricular leukoencephalopathy, which is supposed to be the same thing as leukoaraiosis. It's apparently also known as PVL. And you'll note that the microscopic analysis (histology) indicates that one cause of PVL/leukoaraiosis is demyelination. And there is a laundry list of known causes of leukoaraiosis (see below), not just "vascular problems." So just calling it leukoaraiosis doesn't seem to mean much since that appears to have many etiologies and is a relatively nonspecific MRI finding/description.
Bio
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Non-arteriopathic causes of PVL/leukoaraiosis (note what's second on the list):
Alzheimer's disease
Multiple Sclerosis
Progressive multifocal leukoencephalopathy
HIV encephalitis
Creutzfeldt-Jakob disease
Postinfectious demyelination
Trauma
Radiation therapy
Chemotherapy
Treatment w Cyclosporine or other immunosuppressants
Post hypoxic ischemic encephalopathy
Hyperperfusion syndrome
Vitamin B12 deficiency
Fabry's disease
Proximal myotonic myopathy
To all, thank you as ever for your kind support.
To Bio, I'm 64, apparently not too old for MS. And I found the web site you suggested and it's quite interesting. However, luckily I don't have the symptoms suggested for that malady.
To Elaine. What can I say? If Craig is willing to go through yet more testing and evaluation, and I can sure understand if he's not, Hopkins can't hurt. Maybe if he just takes the attifude of here goes nothing, or here goes only a big interruption in my day, he won't be disappointed if things don't turn out with a diagnosis. My neuro, at least, seems to be something of a lesion counter, but he does prescribe regardless. Would Craig be satisfied with that?
ess
I just can't to this day believe he's not diagnosed. I know you know that, because we speak about it a lot. But to hear his report just irritates me.
Have a good weekend. Try Hopkins! Wait -- Think about it....
Z*
Hi ess,
Well, Craig's MRI from Hopkins also doesn't say 3T but he was assured it was the 3T machine.
His also says,"Multiple scattered T2 flair hyperintensity noted in the periventricular and subcortical white matter. His also says there is a prominent T2 flair hyperintense lesion noted on axila slice 28 perpendicular to the body of the lateral ventricle in the left posterior parietal region.
It also notes parenchymal brain volume loss (brain atrophy).
Yes, the software for their cd's is harder to use than other institutions. We went and got a copy of the actual MRI films to make it easier for other neuros to look at.
I wonder if Craig would get diagnosed at Hopkins????
I agree it is maddening.
Elaine
Hey ~
I'm glad you finally got a 3T! Just wish you had a better radiologist! Aren't I so jaded?
I just wonder what's with this guy/gal who sees these "patchy signal spots" or lesions in your subcortical and periventricular areas AND your cervical spinal cord, and wonders what kind of damage aging has done to you. It boggles my long-in-the-tooth mind.
True, I don't have the learnin' this doc has had, and I'm not a'lookin' at the images, but from here, it looks like MS. Especially given your history. And I'm sure that's what your neuro will reckon. He's put that together before, hasn't he?
I'm glad you'll begin with the Avonex soon! And, like Deb said -- let's pray this is better than the Copaxone experience -- It just HAS to be!
And hopefully he will treat you for the leg pain, too. How frustrating. Is the Lyrica still helping, or has that peetered out?
Feel well,
*
Also, it appears that MS itself can be causative for leukoaraiosis, which is apparently a general term.
See this site:
w w w +dot neuroland +******* followed by cvd then a / then perven_leuko +dot htm.
I've pasted it below, too, but since Medline fritzes these out, I've described it above.
neuroland.com/cvd/perven_leuko.htm
Bio
Ess, I'm sorry I don't remember, but how old ARE you?
Bio
That is crazy! I wonder why radiologist make statements like that, without having the bigger picture. I'm so glad that you'll still be getting treatment for the MS. I hope you do better on Avonex than on Copaxone.
Deb