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RESEARCH in MS at UCI!!
Hi all,
I went to a research talk on MS the other day at UCI and it was very interesting. It made me feel great!! There is much hope out there for us all :) I have put alittle summary in laymans terms below and linked a paper.
The first talk was by Dr Michael Demetriou. He was presenting his research on T-helper cells in MS. He found that T-helper cells are covered in sugars, and that T-helper cells of MS patients have less sugars on their T-helper cells. He added a sugar called GlcNAc to the diet of experimental MS exhibiting mice. These mice seem to have a more RRMS phenotype. He found when he added this sugar to the diet that there was a reduction in relapses!! He did may over experiments too that can be read about in the article linked below. How great would that be for a treatment?? Extra sugar in your coffee??? This was very exciting to me!
1.A. Grigorian, L. Araujo, N. N. Naidu, D. Place, B. Choudhury, M. Demetriou. N-acetylglucosamine inhibits T-helper 1 (Th1) / T-helper 17 (Th17) responses and treats experimental autoimmune encephalomyelitis. Journal of Biological Chemistry, 2011; DOI: 10.1074/jbc.M111.277814
The other speaker Dr Thomas E. Lane spoke about using stem cells to treat MS. Sadly I don't remember much from this talk but I remember the important parts ;). He injected these stem cells into MS mice. These mice have phenotype more like PPMS. He found that he was able not only to stop MS progression but to reverse the already there damage!! He induced remyelination! These mice that couldn't walk after treatment where running around the cage!! This to me was just amazing!
The stem cell treatment is still being perfected before it hits patients but looks very promising. The Sugar treatment is very near clinical trials but they are having a tough time getting companies involved (no money for them in sugar). However, the take home message is that there is much hope out there for us and we have to keep believing and fighting!!
I went to a research talk on MS the other day at UCI and it was very interesting. It made me feel great!! There is much hope out there for us all :) I have put alittle summary in laymans terms below and linked a paper.
The first talk was by Dr Michael Demetriou. He was presenting his research on T-helper cells in MS. He found that T-helper cells are covered in sugars, and that T-helper cells of MS patients have less sugars on their T-helper cells. He added a sugar called GlcNAc to the diet of experimental MS exhibiting mice. These mice seem to have a more RRMS phenotype. He found when he added this sugar to the diet that there was a reduction in relapses!! He did may over experiments too that can be read about in the article linked below. How great would that be for a treatment?? Extra sugar in your coffee??? This was very exciting to me!
1.A. Grigorian, L. Araujo, N. N. Naidu, D. Place, B. Choudhury, M. Demetriou. N-acetylglucosamine inhibits T-helper 1 (Th1) / T-helper 17 (Th17) responses and treats experimental autoimmune encephalomyelitis. Journal of Biological Chemistry, 2011; DOI: 10.1074/jbc.M111.277814
The other speaker Dr Thomas E. Lane spoke about using stem cells to treat MS. Sadly I don't remember much from this talk but I remember the important parts ;). He injected these stem cells into MS mice. These mice have phenotype more like PPMS. He found that he was able not only to stop MS progression but to reverse the already there damage!! He induced remyelination! These mice that couldn't walk after treatment where running around the cage!! This to me was just amazing!
The stem cell treatment is still being perfected before it hits patients but looks very promising. The Sugar treatment is very near clinical trials but they are having a tough time getting companies involved (no money for them in sugar). However, the take home message is that there is much hope out there for us and we have to keep believing and fighting!!
I think we have talked about this stem cell treatment and the reversal in mice before but I don't remember the sugar study. Even if it is old news, it is always good to share because not everyone sees it the first time around. Thanks for passing these on.
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