Has HRT been attempted to alleviate MTHFR symptoms?

[hausofzeus]

has any research been done as to the effects of Hormone Replacement Therapy, slowing down the process of MTHFR C677T.  Unlike most ppl who seem to post questions or concerns re MTHFR, I have successfully and with no complications had my children  and never knew I had this mutation until 4 years ago, I'm now 48.  My onset of problems presented as extreme iron deficiency and with more testing discovered folic acid,b6 and 12 deficiencies.  After several rounds of iv iron and continued problems my hematologist ran this test and presented me with this diagnosis, gave me folic in high doses and went ahead and scheduled me for my next round of iv iron ,which I am having to replace more and more often.  It began at 2 yr intervals and we are now doing the iv iron every four months.  Needless to say I am not thrilled with this arrangement and am desperate to "just go back to being me without having to be *topped off*"  Rambling, sorry, so, I am thinking that if the HRT is working to reverse the side effects of menopause ... then why couldn't it reverse this process as well .. and has anyone tried??  Because, what doesn't seem to be discussed is how draining and exhausting the "depletion" process is when the iron, folic, and b's decide to tank ... and they do ... repeatedly.

[StardustAstara]

I am 61 years old and recently diagnosed as homozygous for C677T MTHFR. I have been on HRT almost continually since having the remainder of my female organs removed at age 37. I had polycystic ovarian disease as a teenager and had my first ovary removed at age 20. Between that time of my total hysterectomy from various continuing "female" problems, I managed to have to normal pregnancies and delivered healthy babies. I also have IgG lambda MGUS, a pre-cursor to multiple myeloma. I have also found a connection between the C677T mutation and multiple myeloma. Since being diagnosed with the MTHFR, I have started taking methylated folic acid. My blood levels of "circulating" folic acid had risen beyond the normal range as well as had my homocysteine levels, hence my doctor testing me for the MTHFR. High levels of circulating, unmethylated Folic acid can cause toxicity in people with MTHFR. That is why you have to take the kind of folic acid that is already broken down chemically (methylated) to a form your body can use. You can buy this without a prescription. I think this toxicity has a lot to do with diagnoses of fibromyalgia, RA and other AI disorders; all of which doctors have "thought" I had through the years at various times. I am currently very healthy with no joint pain, walk daily and act 20 years younger than my years. I have never been over-weight and have never abused alcohol or smoked at all. I think this is one reason I am still so healthy in spite of the dire diagnoses. Would like to connect to other people who have MGUS and MTHFR.

[hausofzeus]

My apologies, I think I may have posted this in the wrong genre ... trying my ? in genetics :/